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| 猪与人肝脏蛋白合成能力匹配研究 | |
| 引用本文： | 张璘,李幼平,程惊秋,彭志英,李胜富,曾养志.猪与人肝脏蛋白合成能力匹配研究[J].四川大学学报(医学版),2004,35(6):781-783. |
| 作者姓名： | 张璘 李幼平 程惊秋 彭志英 李胜富 曾养志 |
| 作者单位： | 1. 四川大学华西临床医学院,卫生部移植工程与移植免疫重点实验室,成都,610041 2. 四川大学华西医院实验医学科临床生化室 3. 云南农业大学,版纳微型猪近交系研究实验室 |
| 基金项目： | 国家自然科学基金 (批准号 3 9993 43 3 )资助 |
| 摘 要： | 目的分析版纳微型猪近交系(BMI)与人肝脏合成蛋白能力匹配程度，从肝脏合成蛋白水平方面探讨猪到人异种肝移植的可行性。方法分别测定BMI和健康志愿者血清总蛋白及白、球蛋白含量，测定其血清各种类球蛋白含量。结果BMI与人肝脏合成白蛋白及α、β球蛋白总体水平无统计学差异。淋巴和浆细胞合成的γ球蛋白含量，BMI约为人的2．4倍，BMI与人之间不同球蛋白含量存在差异。结论BMI肝脏合成白、球蛋白总体水平与人相当，提示BMI肝脏合成蛋白能力与人基本匹配。 |
| 关 键 词： | 版纳微型猪近交系 白蛋白 α球蛋白 β蛋白 γ球蛋白 |
| 修稿时间： | 2004年1月19日 |
Comparison of Hepatic Protein Synthesis Function Between Banna Minipig Inbred Line and Human |
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| Lin Zhang,You-ping Li,Jing-qiu Cheng,Zhi-ying Peng,Sheng-fu Li,Yang-zhi Zeng.Comparison of Hepatic Protein Synthesis Function Between Banna Minipig Inbred Line and Human[J].Journal of West China University of Medical Sciences,2004,35(6):781-783. | |
| Authors: | Lin Zhang You-ping Li Jing-qiu Cheng Zhi-ying Peng Sheng-fu Li Yang-zhi Zeng |
| Institution: | Lab of Transplant Engineering and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China. |
| Abstract: | OBJECTIVE: This is a research aimed at comparing the hepatic protein synthesis function of Banna Minipig Inbred Line (BMI) with that of human so as to evaluate the possibility of porcine liver replacement of human counterpart. METHODS: The venous blood samples from BMI and volunteer participants were collected. The albumin and total protein in the separated sera were tested using Beckman delta CX7 autoanalyzer, and serum protein electrophoresis was performed. RESULTS: No significant differences in albumin and in the percentage and concentration of globulins synthesized in liver (alpha1-, alpha2- and beta-globulin) between BMI and human were observed. The percentage and concentration of gamma-globulin synthesized in the lymphocytes of BMI were significantly higher than those of human. CONCLUSION: The above findings suggested the similarity between BMI liver and human liver in respect to albumin and alpha, beta-globulin synthesis. |
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