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Spinal cord substance P mediates carbachol-induced cardiovascular responses from the rostral ventrolateral medulla |
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| Authors: | Qing Lin Cong De Li Peng Li |
| Affiliation: | aDepartment of Physiology, Shanghai Medical University, Shanghai People's Republic of China bDepartment of Physiology, Yi Chang Medical College, Hubei People's Republic of China |
| Abstract: | Intrathecal (i.t.) infusion of substance P (SP) antagonist, (d-Pro2,d-Trp7.9) P (20 μg), lowered blood pressure profoundly without any significant change of heart rate. The hypertensive and tachycardic responses elicited by microinjection of carbachol (25 ng/site) into the bilateral rostral ventrolateral medulla (rVLM) were blocked by i.t. infusion of SP antagonist. These data provided evidence that an excitatory cardiovascular effect induced by cholinergic system in rVLM may be mediated mainly by the SP receptors in spinal cord. |
| Keywords: | Substance P antagonist Carbachol Spinal cord Rostral ventrolateral medulla Intrathecal infusion Wistar rat |
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