The anticancer activity of lytic peptides is inhibited by heparan sulfate on the surface of the tumor cells |
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| Authors: | Bodil Fadnes ?ystein Rekdal Lars Uhlin-Hansen |
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| Affiliation: | (1) Department of Medical Biochemistry, Institute of Medical Biology, University of Troms?, Norway;(2) Department of Anatomy and Pathology, University Hospital of North Norway, Troms?, Norway;(3) Department of Pathology, Institute of Medical Biology, University of Troms?, Troms?, Norway;(4) Lytix Biopharma, Troms? Science Park, N-9294 Troms?, Norway |
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| Abstract: | Background Cationic antimicrobial peptides (CAPs) with antitumor activity constitute a promising group of novel anticancer agents. These peptides induce lysis of cancer cells through interactions with the plasma membrane. It is not known which cancer cell membrane components influence their susceptibility to CAPs. We have previously shown that CAPs interact with the two glycosaminoglycans (GAGs), heparan sulfate (HS) and chondroitin sulfate (CS), which are present on the surface of most cells. The purpose of this study was to investigate the role of the two GAGs in the cytotoxic activity of CAPs. |
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