| 原发中枢神经系统淋巴瘤临床特点与疗效:40例分析 |
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| 引用本文： | 张冠华,张湘衡,杨群英,赛克,蒋小兵,王振宁,陈忠平,牟永告.原发中枢神经系统淋巴瘤临床特点与疗效:40例分析[J].中国神经肿瘤杂志,2011(1):21-25. |
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| 作者姓名： | 张冠华 张湘衡 杨群英 赛克 蒋小兵 王振宁 陈忠平 牟永告 |
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| 作者单位： | 华南肿瘤学国家重点实验室;中山大学肿瘤防治中心神经外科/神经肿瘤科; |
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| 摘 要： | 背景与目的:原发中枢神经系统淋巴瘤(primary central nervous system lymphoma,PCNSL)近年来在免疫功能正常的人群中发病率有所上升。本研究的目的是探讨PCNSL的临床特征、治疗及预后。方法:回顾性分析经病理证实的40例PCNSL的临床资料。结果:40例患者中24例(60.0%)主要表现为颅内高压;21例(52.5%)单发病灶;28例(70.0%)为弥漫大B细胞淋巴瘤。12例(30.0%)手术全切肿瘤,中位KPS评分70;14例(35.0%)接受HD-MTX为主的化疗加全脑放疗;19例(47.5%)接受鞘内化疗。40例患者Kaplan-Meier分析总中位生存时间为26个月,2年生存率65.2%;HD-MTX联合全脑放疗组患者完全缓解率73.3%,中位生存时间38.5个月,2年生存率80.6%。结论:PCNSL患者临床表现主要为颅内压增高,单发病灶多见,B细胞亚型多见,HD-MTX联合适当剂量的全脑放射治疗可延长生存期,年龄、术后KPS评分影响预后。
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| 关 键 词： | 中枢神经系统淋巴瘤 化疗 放疗 预后 |
A Prognosis Analysis of 40 Cases of Primary Central Nervous System Lymphoma |
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| Guan-hua Zhang,Xiang-heng Zhang,Qun-ying Yang,Ke Sai,Xiao-bing Jiang,Zhen-ning Wang,Zhong-ping Chen,Yong-gao Mou, .State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center Guangzhou ,P.R.China.A Prognosis Analysis of 40 Cases of Primary Central Nervous System Lymphoma[J].Chinese Journal of Neuro-Oncology,2011(1):21-25. |
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| Authors: | Guan-hua Zhang Xiang-heng Zhang Qun-ying Yang Ke Sai Xiao-bing Jiang Zhen-ning Wang Zhong-ping Chen Yong-gao Mou State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer Center Guangzhou PRChina |
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| Institution: | Guan-hua Zhang1,2,Xiang-heng Zhang1,Qun-ying Yang1,Ke Sai1,Xiao-bing Jiang1,Zhen-ning Wang1,Zhong-ping Chen1,Yong-gao Mou1,2 1.State Key Laboratory of Oncology in South China,Sun Yat-sen University Cancer Center Guangzhou 510060,P.R.China,2.Department of Neurosurgery/Neuro-oncology,Sun Yat-sen University Cancer Center,Guangzhou 510060 |
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| Abstract: | BACKGROUND & OBJECTIVE: In recent years,the incidence of primary central nervous system lymphoma(PCNSL) increases in the immunocompetent patients.The purpose of this study is to explore the clinical characteristics,treatment and the prognosis of PCNSL.METHODS: Forty pathology-confirmed PCNSL cases were analyzed retrospectively.RESULTS: Of the 40 patients,24(60.0%) had increased cranial pressure as the major symptom.Twenty-one(52.5%) had single tumor location.Twenty-eight(70.0%) had diffuse large B-cell lymp... |
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| Keywords: | Central nervous system lymphoma Chemotherapy Radiotherapy Prognosis |
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