血清CA125水平监测与先兆流产预后关系的研究

目的探讨糖类抗原125(CA125)对先兆流产预后的临床价值。方法应用微粒子酶免疫分析法(MEIA)检测115例具有先兆流产症状的孕妇治疗前及治疗后1~4周的血清CA125水平。结果最终流产孕妇血清CA125水平显著高于保胎成功者及正常孕妇(P<0.01),且随着治疗时间的推移而递增,其首次检测最低值为52.4 U/m l,检测敏感性为97.56%,特异性为90.54%。结论血清CA125水平的监测对先兆流产的预后判断具有较高的临床应用价值,建议以52.4 U/m l作为临床判断危险的界限。

Study on the relationship between the serum CA125 level and the prognosis of the threatened abortion

Objective To study the clinical significence of CA125 in predicting the prognosis of threatened abortion. Methods The serum CA125 from 115 patients with threatened abortion before treatment and 1-4 weeks after treatment were tested by Abbott micropurticle enzyme immunoassay(MEIA) method. Results The serum CA125 level of the inevitable abortion gravidas was significantly higher than that of normal or evitable abortion gravidas(P<0.01),and it increased by degree and by time in inevitable abortion gravidas.The lowest serum CA125 level was 52.4 U/ml in the first detection of all abortive gravidas,the sensitivity and the specificity of the detection were 97.56% and 90.54% respectively. Conclusions Monitoring of the serum CA125 level has highly clinical value in predicting the prognosis of threatened abortion.It suggested that 52.4 U/ml was the threshold level.