血浆VEGF、TPS、TuM2-PK水平在肺癌介入治疗前后的表达及意义

目的探讨肺癌(LC)患者介入治疗前后血清血管内皮生长因子(VEGF)、组织多态特异性抗原(TPS)、肿瘤型M2丙酮酸激酶(TU M2-PK)的表达及意义。方法分析该院自2013年1月至2015年1月行介入治疗的肺癌患者60例,采用酶联免疫吸附法检测前1天、术后1、3、7、14、28d,VEGF、TPS、TuM2-PK水平,以及不同治疗结局患者VEGF、TPS、TuM2-PK水平的变化。同期进行健康体检的患者40例,为健康对照组。结果观察组患者介入治疗前1、3、7、14、28d的VEGF、TPS、TuM2-PK水平与对照组比较(P0.05,P0.01)。部分缓解患者的VEGF、TPS、TuM2-PK水平较治疗前比较均有显著改善,而病情稳定和病情进展者,VEGF、TPS、TuM2-PK水平较治疗前比较均有明显升高(P0.05)。结论肺癌介入治疗前后,VEGF、TPS、TuM2-PK水平均显著升高,且治疗效果越差,VEGF、TPS、TuM2-PK水平越高,可以作为肺癌介入治疗的检测指标。

Levels of plasma VEGF,TPS and TuM2-PK before and after interventional therapy in lung cancer

Objective To explore the expression and significance of vascular endothelial growth factor (VEGF),tissue polypeptide specificity antigen (TPS) and tumor type M2 pyruvate kinase (TuM2-PK) before and after interventional therapy in lung cancer (LC).Methods Sixty cases of LC treated by interventional treatment in our hospital from January 2013 to January 2015 were analyzed.The levels of VEGF,TPS and TuM2-PK on preoperative 1 d,postoperative 1,3,7,14,28 d were detected by enzyme-linked immunosorbent assay(ELISA).The change of VEGF,TPS and TuM2-PK levels in the patients with different treatment outcomes was observed.Contemporaneous 40 individuals undergoing healthy physical examination served as the healthy control group.Results The levels of VEGF,TPS,TuM2-PK on preoperative 1d,postoperative 3,7,14,28 d had statistical differences between the observation group and control group (P<0.05,P<0.01).Compared with pre-treatment,the levels of VEGF,TPS and TuM2-PK in partial remission patients were significantly improved,which in the patients with stable and progressive condition,the levels of VEGF,TPS and TuM2-PK were significantly increased (P<0.05).Conclusion The levels of VEGF,TPS and TuM2-PK are significantly elevated before and after interventional treatment in LC patients,moreover the worse the therapeutic efficacy,the higher the levels of VEGF,TPS and TuM2-PK,which can be used as the detection indexes of LC interventional treatment.