首发精神分裂症患者血清BDNF、IL-6、Hcy水平与认知功能障碍的关系

目的探讨首发精神分裂症患者血清脑源性神经营养因子(BDNF)、白细胞介素(IL)-6、同型半胱氨酸(Hcy)水平与认知功能障碍的关系。方法选择2015年1月至2016年1月恩施州优抚医院135例精神分裂症患者(患者组)和130例精神健康志愿者(对照组)作为研究对象。采用酶联免疫吸附技术(ELISA)检测IL-6、BDNF水平,循环酶法测定Hcy水平,用阳性和阴性症状评定量表(PANSS)评定精神症状,威斯康星卡片分类测验(WCST)评定认知功能并分析其相关性。结果患者组BDNF水平显著低于对照组,患者组IL-6、Hcy水平显著高于对照组,差异有统计学意义(P0.05)。患者组WCST的错误应答数、持续性错误数、总应答数均显著高于对照组,完成分类数、正确应答数均显著低于对照组,差异有统计学意义(P0.05)。BDNF、IL-6、Hcy水平与PANSS的阴性症状因子分数、WCST的总应答数、持续错误数、错误应答数、完成分类数具有明显的相关性。结论首发精神分裂症患者血清Hcy、IL-6、BDNF水平与患者的精神症状及认知功能存在一定联系,在一定程度上证明了患者神经-体液-免疫调节网络调节机制的存在,并在该病的发生、发展中的协同作用。

Relationship between serum levels of BDNF,IL-6 and Hcy with cognitive function impairment in patients with first episode schizophrenia

Objective To explore the relationship between the levels of serum BDNF,IL-6 and Hcy with cognitive impairment in the patients with first episode schizophrenia.Methods One hundred and thirty-five patients with schizophrenia(patients group)and 130 mental healthy volunteers (control group)in our hospital from January 2015 to January 2016 were selected as the research sub-jects.The levels of IL-6 and BDNF were detected by adopting the enzyme linked immunosorbent assay (ELISA)and Hcy level was detected by using the circulating enzymatic method.The mental symptoms were evaluated by the positive and negative symptom rat-ing scale (PANSS),cognitive function was evaluated by the Wisconsin Card Sorting Test (WCST)and their relationship was ana-lyzed.Results The BDNF level in the patients group was significantly lower than that in the control group,while the Hcy and IL-6 levels were significantly higher than those in the control group,the differences were statistically significant(P<0.05).The WCST errors response number,persistent errors number and total responses number in the patients group were significantly higher than those in the control group,while the complete classification number and correct response number were significantly lower than those in the control group,the differences were statistically significant (P<0.05).The levels of BDNF,IL-6 and Hcy had significant cor-relation with the WCST total responses number,persistent errors number,errors response number and complete classification num-ber.Conclusion The levels of serum Hcy,IL-6 and BDNF in the patients with first episode schizophrenia have a certain relation with the mental symptoms and cognitive function,which demonstrates the existence of nerve-humor-immune regulation network regulation mechanism in a certain degree and plays a synergic action in the occurrence and development of schizophrenia.