| AFP和GP73检测对肝硬化患者癌变的预警价值 |
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| 引用本文： | 钱海根,刘超群,胡焉凡. AFP和GP73检测对肝硬化患者癌变的预警价值[J]. 国际检验医学杂志, 2017, 38(3). DOI: 10.3969/j.issn.1673-4130.2017.03.013 |
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| 作者姓名： | 钱海根 刘超群 胡焉凡 |
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| 作者单位： | 浙江省金华市中医医院检验科 321017 |
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| 基金项目： | 浙江省金华市科技指导性计划资助项目(2011-3-014)。 |
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| 摘 要： | 目的探讨甲胎蛋白(AFP)、高尔基体蛋白73(GP73)对肝硬化患者肝癌发生风险的预警价值。方法采用化学发光法和酶联免疫吸附法分别检测AFP和GP73水平,对50例肝硬化患者进行跟踪随访24个月,了解肝癌发生情况,分析比较AFP、GP73预测肝硬化患者发生肝癌风险的价值。结果肝硬化患者随访18、24个月GP73(+)的癌变率显著高于AFP(+),差异有统计学意义(P0.05)。结论 AFP、GP73对肝硬化癌变均有预测价值,且GP73更具有预警价值。
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| 关 键 词： | 甲胎蛋白 高尔基体蛋白73 肝硬化 |
Forewarning value of AFP and GP7 3 detection in canceration of patients with liver cirrhosis |
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| QIAN Haigen,LIUChaoqun,HUYanfan. Forewarning value of AFP and GP7 3 detection in canceration of patients with liver cirrhosis[J]. International Journal of Laboratory Medicine, 2017, 38(3). DOI: 10.3969/j.issn.1673-4130.2017.03.013 |
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| Authors: | QIAN Haigen LIUChaoqun HUYanfan |
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| Abstract: | Objective To evaluate the forewarning value of alpha-fetoprotein (AFP)and golgi protein73(GP73)in canceration of the patients with liver cirrhosis.Methods The levels of AFP and GP73 were respectively tested by chemiluminescence immuno-assay and ELISA.Fifty patients with liver cirrhosis were performed 24-month follow up for understanding the liver cancer occur-rence situation.The value of AFP and GP73 for predicting the liver cancer occurrence risk in the patients with liver cirrhosis was analyzed and compared.Results The canceration rate after 18,24 months follow up in the liver cirrhosis patients with GPP(+) was significantly higher than that with AFP(+),the difference was statistically significant(P>0.05).Conclusion AFP and GP-73 all have the predictive value for canceration of liver cirrhosis,moreover GP73 has more forewarning value. |
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| Keywords: | alpha-fetoprotein golgi protein 73 liver cirrhosis |
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