甲状腺过氧化物酶抗体在冠心病患者中的检测价值

目的探讨甲状腺过氧化物酶抗体(TPO-Ab)在冠心病患者中的检测价值。方法回顾性分析2014年1月至2015年12月该院行冠状动脉造影检查的240例患者,左冠状动脉投射4个体位,右冠状动脉投射2个体位,记录造影结果,并采用Gensini积分法进行评定;相关性分析采用Spearman法。结果 TPO-Ab滴度增高共计16例,其中冠状动脉粥样硬化组2例,冠状动脉粥样硬化性心脏病组14例;TPO-Ab阳性患者Gensini积分为(39.56±10.23)分,与TPO-Ab阴性(17.20±8.85)分]相比,差异具有统计学意义(P0.05);TPO-Ab与Gensini积分呈正相关(r=0.1132,95%CI为0.099 8~0.269 1,P0.05)。结论甲状腺功能正常的人群,TPO-Ab增高可能会提高冠心病的发病风险,并且伴有更严重的冠脉狭窄。

The detection value of Resistance to thyroid peroxidase antibodies in patients with coronary heart disease

Objective To explore the detection value of resistance to thyroid peroxidase(TPO-Ab)antibodies in patients with coronary heart disease.Methods A retrospective analysis was performed on 240 patients with coronary angiography in our hospital from January 2014 to December 2015.Research objects were given coronary angiography examination,4 and 2 positions were projected for left coronary artery and right coronary artery,respectively.Counted the imaging results,and the Gensini score method was used for assessing.Spearman method was used for the correlation analysis.Results of A total of 16 cases were diagnosed with TPO-Ab drops increased,among which 2 case of coronary atherosclerosis and 14 cases of coronary atherosclerotic heart disease.Compared with the TPO-Ab negative patients (17.20-8.85)the Gensini score for TPO-Ab positive patients (39.56 4±10.23)increased significantly(P＜0.05).TPO-Ab and Gensini score has a significant positive correlation (r =0.113 2,95 ％ CI 0.099 8-0.269 1,P＜0.05).Conclusion TPO-Ab increased the risk of coronary heart disease,and more severe coronary artery stenosis in patients with normal thyroid function.