类风湿性关节炎合并核抗体阳性的临床意义

目的了解类风湿性关节炎(RA)合并核抗体(抗-ANA)阳性的荧光模式和靶抗原分布情况,以及抗-ANA在RA中的影响。方法收集2014-2015年该院风湿科860例RA患者的类风湿因子(RF)、环瓜氨酸抗体(抗-CCP)及抗-ANA等资料,以抗-ANA情况分为抗-ANA阳性组与抗-ANA阴性组,分析2组RA患者RF、抗-CCP血清水平的差异;统计RA合并抗-ANA阳性的荧光模式和靶抗原、抗体分布情况。结果 860例RA合并抗-ANA阳性率37.6%,RA合并抗-ANA阳性的荧光模式以核颗粒型,抗-SSA阳性为主(21.7%);抗-ANA阳性组与抗-ANA阴性组RF和抗-CCP血清水平比较,差异均有统计学意义(P0.05)。结论 RA合并抗-ANA阳性可表现出不同的荧光模式和靶抗原,以核颗粒型,抗-SSA阳性为主。抗-ANA阳性组与抗-ANA阴性组RA患者在关节炎性反应严重程度以及骨质破坏程度方面存在差异,抗-ANA阳性对RA疾病的进展具有一定的促进作用。

The clinical significance of rheumatoid arthritis merger antinuclear antibody positive

Objective To understand the fluorescence pattern of antinuclear antibody(ANA)and the distribution of target anti-gen and ANA′s impact on rheumatoid arthritis(RA)RA.Methods The data of rheumatoid factor(RF)and anti-cyclic citrullinated peptide antibodies(anti-CCP antibodies)and ANA of 860 RA patients during 2014-2015 were collected and divided into 2 groups according to the ANA levels.The differences of RF and anti-CCP antibodies level between 2 groups were analyzed.Analyzed the fluorescence pattern of RA merger ANA and the distribution of target antigen by statistical.Results Of the 860 RA patients,the positive rate of ANA was 37.6%,the major fluorescence pattern of RA merger ANA was speckled pattern,anti SSA positive rate was 21.7%.The RF and anti-CCP antibodies level had statistical difference between ANA positive group and ANA negative group (P <0.05).Conclusion RA merger ANA positive can show different fluorescence patterns and target antigen,the speckled pattern and anti-SSA positive are the main pattern.The severity of arthritis symptoms and the degree of bone destruction between ANA positive group and ANA negative group were difference.Anti-ANA positive has a certain promoting effect on the progression of RA disease.