血清可溶性CD44检测对急性髓系白血病的诊断分型价值研究

目的探讨血清可溶性CD44(solCD44)检测对于急性髓系白血病(AML)的临床诊断分型价值。方法选取2014年1月至2016年1月该院血液科收治的AML患者80例,包括初诊31例、复发24例、缓解25例。同期健康体检者40例为对照组。检测比较各组患者的血清solCD44std、solCD44v5、solCD44v6水平变化。结果 AML患者的血清solCD44s、solCD44v5、solCD44v6水平在初诊、复发组中显著高于缓解组及对照组(P0.05),而缓解组与对照组比较差异无统计学意义(P0.05);不同FAB分型(M1+M2)、M3、M4、M5的血清solCD44std、solCD44v5、solCD44v6水平比较差异有统计学意义,且M3型显著高于非M3型(P0.05)。结论血清solCD44尤其是solCD44std水平与AML患者病情活动变化密切相关,可作为AML的诊断分型、预后判断及复发预测的血清学参考指标。

Values of serum soluble CD44 in diagnostic classification of acute myeloid leukemia

Objective To evaluate the clinical values of serum soluble CD44 (solCD44) in diagnostic classification of acute myeloid leukemia (AML).Methods 80 patients with AML who admitted in Department of Hematology in our hospital from January 2014 to January 2016 were enrolled.Among these 80 cases,there were 31 cases newly diagnosed,24 cases refractory and 25 cases remission.40 healthy volunteers were set as the control group.The levels of solCD44s,solCD44v5 and solCD44v6 were measured and compared of each group.Results The levels of serum solCD44s,solCD44v5 and solCD44v6 in newly diagnosed and refractory group of AML patients were significantly higher than those in the control group and remission group (P<0.05),while there were no significant differences between remission group and (P>0.05);There were significant differences of serum levels of solCD44s,solCD44v5,solCD44v6 in different FAB subgroups (M1+M2),M3,M4 and M5,meanwhile,the serum levels of solCD44s,solCD44v5,solCD44v6 in M3 type were significantly higher than those in non-M3 type (P<0.05).Conclusion The level of solCD44 especially solCD44std is closely related to the changes of disease activity in patients with AML.Serum solCD44 levels can be used as serological reference indicators of diagnostic classification,prognosis and recurrence prediction for AML.