小儿慢性迁延性腹泻与食物不耐受的相关性分析

目的通过检测并对比慢性迁延性腹泻病患儿与健康体检儿童血清中食物特异性IgG抗体的水平,分析小儿慢性迁延性腹泻病的发生与食物不耐受是否具有相关性。方法随机抽取深圳市儿童医院2015年1-12月临床诊断为慢性迁延性腹泻病的患儿105例,并选取健康体检儿童94例作为对照组,采用酶联免疫法检测受检者血清中14种食物过敏原特异性IgG抗体的浓度水平。结果慢性迁延性腹泻病多见于0~1岁的小婴儿,105例慢性迁延性腹泻病患儿的14种食物特异性IgG抗体阳性率水平从高到低依次排列为:牛奶、鸡蛋、西红柿、大米、小麦、鳕鱼、玉米、牛肉、大豆、鸡肉、猪肉、蘑菇、虾和蟹;94例健康体检儿童的14种食物特异性IgG抗体阳性率水平从高到低依次排列为:牛奶、鸡蛋、西红柿、大米、小麦、大豆、鳕鱼、玉米、牛肉、蟹、鸡肉、蘑菇、虾和猪肉;其中牛奶、牛肉和大豆的食物特异性IgG在两组间的比较中具有统计学意义(P0.05)。结论食物不耐受有可能是婴幼儿发生慢性迁延性腹泻病的重要病因之一,可以通过合理调整小儿饮食治疗小儿慢性迁延性腹泻病。

The relationship analysis between children with chronic persistent diarrhea and food intolerance test

Objective To investigate and compare the level of food specific IgG antibody between children with chronic diarrhea and healthy children,analyze the correlation between chronic persistent diarrhea and food intolerance.Methods The research objective of 105 cases was obtained from in-patient children in Shenzhen children′s hospital diagnosed as chronic persistent diarrhea and 94 cases diagnosed not diarrhea as control group in the year of 2015.The level of fourteen food allergen specific IgG in serum was detected using enzyme-linked immunosorbent (ELISA) in 199 cases.Results Chronic persistent diarrhea was more observed in 0-1 years old of infants.The positive rate of 14 food allergen specific IgG in 105 cases of children with chronic persistent diarrhea in turn from high to low was milk,eggs,tomatoes,rice,wheat,cod,corn,beef,soybeans,chicken,pork,mushrooms,shrimp and crab;14 food allergen specific IgG in 94 cases of children not with diarrhea in turn from high to low was arranged as follows:milk,eggs,tomatoes,rice,wheat,soybeans,cod,corn,beef,crab,chicken,mushroom,shrimp and pork.Among them the level of milk,beef and soybeans in the comparison of the two groups was significantly different(P<0.05).Conclusion Food intolerance was one of the important factors caused chronic persistent diarrhea in children.Reasonable diet for children may be the effective treatment of chronic persistent diarrhea.