血清中CYFRA21-1和SCCAg水平对宫颈癌放疗患者预后的评价作用

目的探讨宫颈癌患者血清中细胞角蛋白19片段抗原(CYFRA21-1)和鳞状上皮细胞癌抗原(SCCAg)水平对宫颈癌放疗患者肿瘤预后的影响。方法选取2008年10月至2011年10月间在该院经病理检查确诊宫颈癌的患者100例。采用放射免疫检测法检测患者血清中CYFRA21-1和SCCAg水平,采用Pearson和Spearman相关性探讨血清中CYFRA21-1和SCCAg水平与宫颈癌患者临床特征的关系,采用COX回归模型探讨CYFRA21-1和SCCAg水平与子宫颈癌患者死亡或转移复发的关系。结果 100例宫颈癌患者,出现终点事件者21例,淋巴结转移率(LNR)4期患者出现终点事件的风险较高,约45.5%,CYFRA21-1和SCCAg水平均与宫颈癌患者癌胚抗原125(CA125)、肿瘤N分期、肿瘤浸润深度呈正相关,与患者年龄无明显相关。肿瘤分化程度(P=0.013)、血清CYFRA21-1水平(P=0.02)、血清SCCAg水平(P=0.03)、肿瘤浸润深度(P=0.04)是宫颈癌患者出现终点事件的独立危险因素。结论 CYFRA21-1和SCCAg水平与宫颈癌放疗患者预后密切相关。

Evaluation of serum CYFRA21-1 and SCCAg levels in the prognosis of cervical cancer patients with radiotherapy

Objective To investigate the effect of serum CYFRA21-1 and SCCAg levels on the prognosis of patients with cervical cancer radiotherapy.Methods 100 cases of cervical cancer were diagnosed by pathological examination in our hospital from October 2008 and October 2011,Using radioimmunoassay(RIA) in detection of serum CYFRA21-1 and SCCAg level,Pearson and Spearman correlation is used to study the relationship between serum CYFRA21-1 and SCCAg level and cervical cancer patients with clinical features,using the Cox regression model of CYFRA21-1 and SCCAg level and uterine cervix cancer death or recurrence and metastasis of the relationship.Results 100 cases of patients with cervical cancer,endpoint events in 21 cases,LNR4 patients appear higher risk of endpoint events about 44.3%,CYFRA21-1 and SCCAg levels were with cervical cancer patients with CA-125 values,tumor staging,depth of tumor invasion into positive correlation,and the age of patients,no significant correlation,tumor differentiation(P=0.013),serum CYFRA21-1 levels(P=0.02),serum SCCAg levels(P=0.03),depth of tumor invasion(P=0.04) is cervical cancer patients with endpoint events independent risk factors.Conclusion CYFRA21-1 and SCCAg levels were closely related to the prognosis of patients with cervical cancer radiotherapy.