感染性肺炎患儿FIB、PCT、hs-CRP水平的变化及意义

目的观察小儿感染性肺炎患者血浆纤维蛋白原(FIB)、血清降钙素原(PCT)、超敏C反应蛋白(hs-CRP)水平变化及意义。方法将细菌感染性肺炎(细菌组)104例、非细菌感染(非细菌组)109例和健康体检儿童110例(对照组)纳入本研究,观察各组FIB、PCT、hs-CRP水平变化。结果细菌组患者FIB、PCT、hs-CRP均高于非细菌组和对照组(P0.05)。病毒组、支原体组和衣原体组患儿FIB、PCT、hs-CRP水平比较,差异无统计学意义(P0.05)。非细菌组、细菌组联合检测阳性率明显高于单项指标检测阳性率(P0.05)。细菌组中患儿FIB水平与PCT、hs-CRP均呈正相关(r分别为0.445、0.396,P0.05)。PCT与hs-CRP呈正相关(r=0.487,P=0.021)。结论 FIB、PCT、hs-CRP联合检测能有效鉴别细菌感染和非细菌感染,对肺炎的病原体感染的诊断和疗效评价具有重要临床意义。

Change of serum FIB,PCT and hs-CRP in children patients with infectious pneumonia and its clinical significance

Objective To observe the change of serum fibrinogen(FIB) ,procalcitonin(PCT) and hypersensitve C reactive protein (hs-CRP) in children with infectious pneumonia and its clinical significance .Methods One hundred and four cases of children with bacterial infectious pneumonia (bacterial group) ,109 cases with non-bacterial infectious pneumonia(non-bacterial group) and 110 healthy children under going physical examination (control group) were included into this study ,the serum FIB ,PCT and hs-CRP level were observed in each group .Results The FIB ,PCT and hs-CRP levels in the bacterial group were higher than those in the non-bacterial group and control group (P<0 .05);the FIB ,PCT and hs-CRP had no statistical difference among the virus group , mycoplasma group and chlamydia group had no atoctistical(P>0 .05) .The positive rate of combined detection of FIB ,PCT and hs-CRP in the non-bacterial group and bacterial group was significantly higher than that of single index detection (P<0 .05) .The FIB level in the bacterial group was positively correlated with PCT and hs-CRP(r=0 .445 ,0 .396 ,P<0 .05) .PCT and hs-CRP showed a positive correlation (r=0 .487 ,P=0 .021) .Conclusion The combined detection of FIB ,PCT and hs-CRP can effectively identify bacterial infection and non-bacterial infection and which has an important clinical significance for the diagnosis and treatment of pathogenic infection of pneumonia .