食物不耐受特异性IgG抗体与口腔黏膜病的相关性研究

目的通过口腔黏膜病患者对14种食物不耐受特异性IgG抗体进行检测,为口腔黏膜病的诊断治疗和预防提供重要实验室依据。方法采用酶联免疫吸附法对两组1 223例口腔黏膜病患者进行食物不耐受特异性IgG抗体水平检测。结果1 023例口腔黏膜病患者组中出现食物不耐受特异性IgG抗体总阳性率为78.3%,对照组出现食物不耐受特异性IgG抗体总阳性率总阳性率为54.5%,差异具有统计学意义(P0.05)。5种类型口腔黏膜病患者出现食物不耐受特异性IgG抗体阳性率依次为炎性肉芽肿(84.21%)、白斑(79.22%)、扁平苔藓(79.02%)、溃疡(77.03%)、腺性唇炎(67.05%)。患者组食物不耐受特异性IgG抗体中鸡蛋不耐受特异性IgG抗体阳性率为最高。结论食物不耐受特异性IgG抗体的检测对口腔黏膜病早期的发生、治疗和延缓疾病进程具有一定的临床意义。

Study on correlation between food intolerance specific IgG antibody and oral mucosal disease

Objective To detect 14 kinds of food intolerance specific IgG antibodies in the patients with oral mucosal disease to provide an important laboratory evidence for the diagnosis,treatment and prevention of oral mucosal disease.Methods The enzyme linked immunosorbent assay(ELISA)was used to detect the food intolerance specific IgG antibody levels.Results The total posi-tive rate of food intolerance specific IgG antibody in 1 223 patients with oral mucosal disease was 78.3%,while which in the control group was 54.5%,the difference between the two groups was statistically significant (P<0.05).The positive rates of food intoler-ance specific IgG antibody in 5 types of oral mucosal disease were 84.21% for inflammatory granuloma,79.22% for white spot, 79.02% for lichen planus,77.03% for ulcer and 67.05% cheilitis glandularis.The positive rate of egg intolerance specific IgG anti-body was highest in the patients group.Conclusion The detection of food intolerance specific IgG antibodies has a certain clinical significance in the occurrence and treatment of the early stage of oral mucosal disease,and delay of disease progression.