乌司他丁对脓毒症脏器的保护作用

脓毒症是危重症医学研究的热点与难点,是危重症患者死亡的常见原因。其发病机制复杂,与机体多系统、多器官病理生理改变密切相关,而有效的药物应用以维持机体内环境稳态,为抢救治疗措施的实施赢得更多时间。乌司他丁是从人体尿液中分离纯化的一种胰蛋白酶抑制剂,无免疫原性,主要通过调控炎性介质释放以维持肠道黏膜完整性、改善凝血功能、降低血管通透性,进而阻断全身炎性反应综合征/多脏器功能障碍综合征的进程,具有明显的脏器功能保护作用。

Organ Protection of Ulinastin in Sepsis

Sepsis was not only a hotspot but also a difficult issue in the research of critical care medicine,which was a common reason resulting in the death of patients with crisis.Its pathogenesis was complicated and closely associated with multisystems and multiorgans of the body,and the effective drug to maintain homeostasis was applicated to win more time for treatment.Ulinastatin,as a kind of pancreatic trypsin inhibitor,separated and purified from human urine,which had no immunogenicity,blocked the progress of SIRS/MODS by regulating inflammatory mediators expression to keep intestinal mucosa integrity,improve thromboplastic function and reduce vasopermeability,which played an important role in the protection of multiorgans.