2型糖尿病合并冠心病血瘀证患者胱抑素C水平与冠状动脉狭窄程度的相关性研究

目的：探讨血清胱抑素C（CysC）水平与2型糖尿病合并冠心病血瘀证患者冠状动脉狭窄程度的相关性。方法：将131例经冠状动脉造影检查确诊为冠心病的2型糖尿病血瘀证患者，应用免疫比浊法检测CysC浓度，采用t检验、秩和检验、双变量相关分析评价2型糖尿病合并冠心病血瘀证患者CysC水平与冠状动脉狭窄程度（Gensini积分）的相关性。结果：CysC阳性组Gensini积分较CysC阴性组升高（P〈0．01）。CysC定量分析与Gensini积分双变量相关分析显示，CysC与Gensini积分有明显正相关性（P〈0．05）。结论：2型糖尿病合并冠心病血瘀证患者CvsC定性、定量分析与冠状动脉狭窄程度有明显正相关性。

Correlation Between Cystatin C and Coronary Artery Stenosis Degree in Type 2 Diabetes MeUitus Patients Complicated with Coronary Artery Disease of Blood-stasis Syndrome

Objective： To investigate the correlation between cystatin C and the degree of coronary artery stenosis in type 2 diabetes mellitus（T2DM） patients complicated with coronary artery disease（CAD） of blood-stasis syndrome. Methods. A total of 131 T2DM-CAD patients of blood-stasis syndrome confirmed by coronary angiography received the blood testing of cystatin C with immunoturbidimetry. The cor- relation between cystatin C and Gensini scores of the severity of coronary artery stenosis was analyzed by t-test, rank sum test, and bivariate correlation analysis. Results： The level of Gensini scores in cystatin C positive group was much higher than those in the cystatin C negative group（P〈0.01）. The quantitative analysis revealed that cystatin C was positively correlated with Gensini scores, Cr and UA levels（P〈0.05, P〈0.01）. Conclusion.. The cystatin C level is positively correlated with the degrees of coronary artery stenosis in T2DM-CAM patients with of blood-stasis syndrome.