肠愈宁对溃疡性结肠炎活动期患者血浆D-二聚体及血小板计数的影响

目的：观察肠愈宁对溃疡性结肠炎（UC）活动期患：静血浆D-二聚体和血小板计数（BPC）的影响。方法：对50例治疗组UC活动期患者采用肠愈宁治疗，检测治疗组治疗前后及20例健康对照者的血浆D-二聚体和BPC。结果：2组比较，UC活动期患者血浆D-二．聚体和BPC均高于健康对照组，差异均有显著性意义（P〈0．05）。治疗后，治疗组血浆D-二聚体和BPC较治疗前下降，差异均有显著性意义（P〈0．05），与健康对照组比较，差异均无显著性意义（P〉0．05）。结论：肠愈宁对UC活动期有较好治疗效果；调整D-二聚体水平，抑制血小板活化状态可能是肠愈宁发挥作用的重要机制。

Effects of Changyuning on Plasma D-dimer level and Platelet Count in Patients with Active Ulcerative Colitis

Objective： To observe the impact of Changuning on the plasma level of D-dimer（D-D） and platelet（PLT） count in patients with active ulcerative colitis（AUC）. Methods： The treatment group had 50 patients with AUC, and were treated with Changyuning. Before and after treatment, the plas- ma level of D-D and PLT count in the treatment group were observed and then were compared to those in 20 healthy control subjects. Results： The plasma D-D level and PLT count of active UC pa- tients were higher than the healthy controls before treatment, and the difference was statistically significant（P 〈 0.05）. After treatment, plasma D-D level and PLT count of active UC patients were decreased （P 〈 0.05 compared with those before treatment）, and the differences between healthy control group and treatment group were insignificant（P〉 0.05）. Conclusion： Changyuning has certain therapeutic effect for AUC, and adjusting the level of D-D and inhibition of platelet activation may play important roles in the therapeutic mechanism of Changyuning.