| 有助于t(8;21)急性髓细胞白血病的诊断和预后判断的免疫表型特征 |
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| 引用本文： | 胡晓梅,麻柔. 有助于t(8;21)急性髓细胞白血病的诊断和预后判断的免疫表型特征[J]. 白血病．淋巴瘤, 2007, 16(2): 154-156 |
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| 作者姓名： | 胡晓梅 麻柔 |
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| 作者单位： | 100091,北京,中国中医研究院西苑医院血液科;100091,北京,中国中医研究院西苑医院血液科 |
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| 摘 要： | t(8;21)核型急性髓细胞白血病（AML）是临床常见类型白血病，更多见于FAB分型M2型。由于21号染色体上的AML1基因和8号染色体上的ETO基因发生融合，而产生AML1-ETO融合蛋白。t(8;21) AML具有独特的免疫表型，这些独特的免疫表型特征不仅有助于t(8;21) AML的诊断，而且决定了t(8;21) AML的预后
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| 关 键 词： | 白血病 髓样 急性 t(8,21)核型 免疫表型 诊断 预后 |
| 收稿时间： | 2007-06-15; |
Distinctive immunophenotypic characteristics determined the diagnosis and prognosis in acute myeloid leukemia with t(8;21) |
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| HU Xiao-mei,MA Rou. Distinctive immunophenotypic characteristics determined the diagnosis and prognosis in acute myeloid leukemia with t(8;21)[J]. Journal of Leukemia & Lymphoma, 2007, 16(2): 154-156 |
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| Authors: | HU Xiao-mei MA Rou |
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| Affiliation: | Department of Hematology, Xiyuan Hospital, China Acade－my of Traditional Chinese Medicine, Beijing |
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| Abstract: | Acute myelogenous leukemia (AML) with t(8;21) is common in clinical, it occures most commonly in M2 FAB type. The chromosomal translocation in AML involved the AML1 (acute myeloid leukemia 1) gene on chromosome 21 and the ETO (eight-twenty one) gene on chromosome 8 generates an AML1-ETO fusion protein. AML with t(8;21) has the distinctive immunophenotypies, and these distinctive im－munophenotypic characteristics determine the diagnosis and prognosis in AML with t(8;21) |
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| Keywords: | t(8 |
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