血清尿酸和铁蛋白水平与脑出血预后的相关性

目的 研究血清尿酸和铁蛋白水平与脑出血预后的相关性.方法 选取神经内科收治的60例自发性脑出血患者为研究对象,归为试验组,分别于入院当天,入院第3、7、14天检测试验组所有患者的血清尿酸和血清铁蛋白水平;选取60例健康居民为对照组,检测其血清尿酸和血清铁蛋白水平.结果 脑出血患者预后较好组血糖、白细胞、NIHSS1、NIHSS2、年龄、24 h出血量及舒张压与预后较差组比较,差异均有统计学意义(P<0.05).采用MRS评分发对试验组在发病90 d后的情况进行评价, 34例患者MRS评分≤2分,属于预后较好;有26例MRS评分>2分,属于预后较差;预后较差患者中有2例患者死亡.试验组入院当天、入院第3、7、14天的尿酸水平与对照组比较,差异无统计学意义(P>0.05);预后较好组和预后较差组的尿酸水平差异无统计学意义(P>0.05).试验组预后不同的2亚组血清铁蛋白水平变化趋势一致,从入院当天至入院第7天均呈上升趋势,在入院第14天时有所下降,但整体水平仍相对较高;预后不同的2组血清铁蛋白水平在各时间点的变化差异有统计学意义(P<0.05);试验组患者在入院第3、7、14天的血清铁蛋白水平明显高于对照组(P<0.05).多元线性回归分析发现血清铁蛋白及NIHSS1是影响脑出血预后的独立危险因素,并且发现两个独立危险因素间存在相关性,患者入院第3天的血清铁蛋白水平与NIHSS1呈正相关.结论 血清铁蛋白水平是影响脑出血患者预后的独立危险因素.

Correlation between serum uric acid as well as ferritin levels and prognosis of patients with cerebral hemorrhage

Objective To investigate the the correlation between serum uric acid as well as ferritin levels and prognosis of patients with cerebral hemorrhage.Methods Sixty patients with spontaneous cerebral hemorrhage who were admitted and treated in our hospital from April 2013 to April 2016 were enrolled as experimental group,and the other 60 healthy subjects were enrolled as control group.The levels of serum uric acid were detected on 3,7,14 days after admission in experimental group,which were also detected in control group.Results There were significant differences in blood glucose, white blood cells,NIHSS1,NIHSS2,patient's age, 24h hemorrhage volume and diastolic pressure between patients with better prognosis and patients with poor prognosis (P<0.05).There were no significant differences in the levels of serum uric acid on admission day and on 3,7,14 days after admission in experimental group (P>0.05),and there were no significant differences in the serum levels of uric acid between better prognosis group and poor prognosis group (P>0.05).However there were significant differences in the serum levels of ferritin in different time points between better prognosis group and poor prognosis group (P<0.05).The serum levels of ferritin on 3,7,14 days after admission in experimental group were significantly higher than those in control group (P<0.05).The multiple linear regression analysis showed that serum ferritin and NIHSS1 were independent risk factors influencing patient's prognosis,moreover there was a correlation between the two risk factors,and the levels of serum ferritin were positively correlated to those of NIHSS1 on 3 days after admission.Conclusion The levels of serum ferritin are an independent risk factor influencing the prognosis of patients with cerebral hemorrhage.