| Box-Behnken试验设计优选淫羊藿饮片中淫羊藿苷及总黄酮提取工艺 |
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| 引用本文： | 张振巍,高媛,刘忠良,陈瑶,孙旭,张振兴,石磊. Box-Behnken试验设计优选淫羊藿饮片中淫羊藿苷及总黄酮提取工艺[J]. 中国药师, 2015, 0(9): 1493-1495 |
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| 作者姓名： | 张振巍 高媛 刘忠良 陈瑶 孙旭 张振兴 石磊 |
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| 作者单位： | 解放军第155中心医院 河南开封 475003；;济南军区联勤部药品仪器检验所;济南军区联勤部药品仪器检验所;济南军区联勤部药品仪器检验所;济南军区联勤部药品仪器检验所;济南军区联勤部药品仪器检验所;解放军第155中心医院 |
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| 基金项目： | 济南军区后勤科研计划(编号：CJN10L067) |
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| 摘 要： | 摘 要 目的： 建立淫羊藿饮片醇提生产工艺。方法: 采用Box Behnken试验设计结合效应面法对各工艺参数进行优选，HPLC色谱法和紫外可见分光光度法联合定量评价。结果: 淫羊藿生产最佳提取工艺为：加入15倍量70%乙醇，提取150 min。结论: Box Behnken试验设计适合对因素的水平范围进行合理筛选，该工艺稳定，可行性强。
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| 关 键 词： | 淫羊藿；提取工艺；Box Behnken试验设计；效应面法 |
| 收稿时间： | 2015-03-13 |
| 修稿时间： | 2015-04-28 |
Extraction Process Optimization of Icariin and Total Flavones in Epimedium Pieces by Box-Behnken Design |
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| Zhang Zhenwei,Gao Yuan,Liu Zhongliang,Chen Yao,Sun Xu,Zhang Zhenxing and Shi Lei. Extraction Process Optimization of Icariin and Total Flavones in Epimedium Pieces by Box-Behnken Design[J]. China Pharmacist, 2015, 0(9): 1493-1495 |
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| Authors: | Zhang Zhenwei Gao Yuan Liu Zhongliang Chen Yao Sun Xu Zhang Zhenxing Shi Lei |
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| Abstract: | ABSTRACT Objective: To establish the ethanol extraction process of epimedium pieces. Methods: The process parameters were optimized by Box Behnken design combined with response surface methodology, and HPLC combined with UV was used in the quantitative evaluation. Results: The optimum extraction process of epimedium was as follows: 15 fold amount of 70% ethanol was added and the pieces were extracted for 150 min. Conclusion:Box Behnken design can be used to screen the reasonable level range of factors, and the optimal process is reliable and feasible. |
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| Keywords: | Epimedium Extraction technology Box Behnken experimental design Response surface methodology |
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