红外线及磁场对兔膝骨关节炎滑膜损伤的影响

目的 探讨红外线及磁场对兔膝关节骨性关节炎所造成的滑膜炎症的治疗效果。方法 24只健康雄性新西兰成年白兔采用管型石膏伸直位固定右后肢法复制膝骨关节炎模型。6周后解除石膏固定并随机分为模型组、红外线治疗组（红外组）、磁疗组及红外线和磁场联合治疗组（联合组），每组6只。解除石膏后即开始行物理因子治疗（模型组不作任何处理），分别于治疗开始后1、2、3周每组各处死2只动物，观察关节周围滑膜组织的大体改变，并切取造模肢体关节腔内滑膜组织行组织病理学检测。结果 联合组动物的滑膜病变及增生程度减轻，与红外组和磁疗组有显著性差异（P〈0．05），而红外组与磁疗组之间无显著性差异（P〉0．05）。结论 联合应用红外线和磁场能有效抑制骨关节炎的滑膜炎症，减轻组织破坏。

Effect of Infrared Radiation and Magnetic Fields on Synovitis of Rabbit with Knee Osteoarthritis

ObjectiveTo investigate the effects of infrared radiation and magnetic fields on the synovitis of rabbit with experimental knee osteoarthritis (OA).MethodsTwenty-four New Zealand grown rabbits were duplicated for OA model of the knee by extended fixation technique, and after 6 weeks, all rabbits were unchained from fixation. The rabbits were randomly divided into four groups: control group (no treatment), infrared group (treated with infrared radiation ), magnet-therapy group (treated with magnetic fields ) and the combined therapy group (treated with infrared radiation and magnetic fields). At the ends of the first, second and third week after treatment, 2 rabbits in each group were taken to measure the general change and histopathology of their synovium.ResultsCompared with other groups, the severity of synovitis (include the synovium line cells proliferation, the invading of granulation and blood vessels in the underlayer of synovium, the infiltration of inflammatory cells) declined significantly in combined therapy group. Scores of Ayral's index of combined group were significantly lower than other groups ( P<0.05), and there was no significant difference between infrared group and magnet-therapy group ( P>0.05).ConclusionThe combination of infrared radiation and magnetic fields can efficiently suppress the synovitis of OA and alleviate the tissue's destructions.