| Mice aorta loop grafting： A new model which separate vascular rejection and neointimal formation in chronic rejection |
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| 引用本文： | 陈勇,窦科峰,何勇,孙凯.Mice aorta loop grafting： A new model which separate vascular rejection and neointimal formation in chronic rejection[J].中国人民解放军军医大学学报,2003,18(4):209-212. |
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| 作者姓名： | 陈勇 窦科峰 何勇 孙凯 |
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| 作者单位： | DepartmentofHepatobiliarySurgery,XijingHospital,FourthMilitaryMedicalUniversity,Xi‘an710033,China |
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| 摘 要： | To study the cause and mechanism of transplantation vasculopathy which characterized by accelerated graft arteriosclerosis ( AGA), we estabfished a mouse aorta graft model. Methods: A segment of thoracic aortas of B10. A (2R) mice were transplanted to C57BL/10 mice abdominal aorta by end to side anastomoses. The different time point collected grafts were analyzed by morphological, histochemical and electro microscopic methods. Results:Rejection was manifested as a concentric progressive destruction of the smooth muscle cells. In contrast, the endothelial inflammation and subsequent ncointimal proliferation characteristic of AGA was localized to the regions of turbulent flow, i.e. the junction of the graft with the recipient aorta. Conclusion: This model separates the processes of rejec-tion and neointimal formation which usually manifested together in the lesion of AGA, elucidate that different mecha-nisms control vascular rejection and neointimal formation in chronic rejection.
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| 关 键 词： | 主动脉片段 血管移植 旁路 慢性排斥反应 动脉硬化 动物模型 |
Mice aorta loop grafting: A new model which separate vascular rejection and neointimal formation in chronic rejection |
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| CHEN Yong,DOU Ke-feng,HE Yong,SUN Kai.Mice aorta loop grafting: A new model which separate vascular rejection and neointimal formation in chronic rejection[J].Journal of Medical Colleges of PLA(China),2003,18(4):209-212. |
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| Authors: | CHEN Yong DOU Ke-feng HE Yong SUN Kai |
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| Institution: | CHEN Yong,DOU Ke-feng,HE Yong,SUN Kai
Department of Hepatobiliary Surgery,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China |
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| Abstract: | Objective: To study the cause and mechanism of transplantation vasculopathy which characterized by accelerated graft arteriosclerosis (AGA) , we established a mouse aorta graft model. Methods: A segment of thoracic aortas of B10. A (2R) mice were transplanted to C57BL/10 mice abdominal aorta by end to side anastomoses. The different time point collected grafts were analyzed by morphological, histochemical and electro microscopic methods. Results: Rejection was manifested as a concentric progressive destruction of the smooth muscle cells. In contrast, the endothelial inflammation and subsequent neointimal proliferation characteristic of AGA was localized to the regions of turbulent flow, i. e. the junction of the graft with the recipient aorta. Conclusion: This model separates the processes of rejection and neointimal formation which usually manifested together in the lesion of AGA, elucidate that different mechanisms control vascular rejection and neointimal formation in chronic rejection. |
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| Keywords: | chronic rejection animal model transplantation |
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