新辅助化疗在宫颈癌术前治疗中的应用

目的探讨新辅助化疗（NACT）在子宫颈癌治疗中的应用价值。方法选择2000年1月-2005年12月连云港市第一人民医院收治的42例宫颈癌患者，所有患者术前均行2个疗程化疗（间隔21d），化疗方案为PVB或BIP，化疗后2周进行手术根治。结果NACT总有效率为78．6％，其中完全缓解28．6％，部分缓解50．0％，局部肿瘤体积缩小显著，术后病理显示宫颈残留42．2％，宫旁浸润4．8％，盆腔淋巴结转移7．1％。患者术后恢复良好，有宫颈残留、宫旁浸润、盆腔淋巴结转移者，术后行局部放疗或术后巩固化疗，29例患者已随访3a，死亡3例，其余正随访中。结论NACT作为宫颈癌患者术前治疗是安全有效的，可以缩小肿瘤体积，提高手术成功率。

Application of New Pre - Operation Auxiliary Chemotherapy in Treating Cervical Carcinoma

Objective] To explore the application value of new pre-operation auxiliary chemotherapy (NACT) in treating cervical carcinoma. Methods] Two periods of chemotherapy were conducted on 42 cervical carcinoma patients who were collected since January of 2001 to December of 2005 (every 21 days); the chemotherapy projects were PVB and BIP; operation was made two weeks afterwards. Results] The total effective rate of NACT was 78.6%, 28.6% of which was complete remission; 50.0% of which was partial remission; local carcinoma bulk decreased significantly; the post-operation pathology indicated that there was 42.2% of cervical remains, 4.8% of uterus infiltration and 7.1% of pelvic cavity lymph node metastasis. Those patients received local radiotherapy and chemotherapy after the operation, 29 patients was followed up for 3 years, 3 of them died. Conclusion] NACT is safe and effective for the pre-operation treatment of cervical carcinoma, which can reduce the carcinoma bulk and increase the successful rate of the operation.