| MDR1C3435T基因多态性与芬太尼术后镇痛效应的关系 |
| |
| 引用本文： | 邓婕,李敏,吴晓智,陈国忠,宋洪涛.MDR1C3435T基因多态性与芬太尼术后镇痛效应的关系[J].中国临床药学杂志,2011(3):129-132. |
| |
| 作者姓名： | 邓婕 李敏 吴晓智 陈国忠 宋洪涛 |
| |
| 作者单位： | 南京军区福州总医院药学科;沈阳药科大学药学院;南京军区福州总医院麻醉科; |
| |
| 摘 要： | 目的探索MDR1C3435T基因多态性与芬太尼术后镇痛效应的关系。方法术后随访患者并记录芬太尼镇痛使用量及不良反应发生情况，采用聚合酶链反应一限制性片段长度多态性（eCR-RFLP）技术对129例患者进行基因分型，比较不同基因型间芬太尼镇痛效应的差异。结果129例患者中、CC型51例（39．5％）、CT型57例（44．2％）、111型21例（16．3％）。CT型、TT型患者24h芬太尼镇痛使用量显著低于CC型（P〈0．05），TT型患者48h芬太尼镇痛使用量显著低于CC型（P〈0．05），CT型与CC型48h芬太尼镇痛量、不同基因型组间不良反应发生率差异无统计学意义。结论MDR1C3435T与术后不良反应无相关性，但与芬太尼术后镇痛使用量具有相关性，该基因型可能成为疼痛个体化治疗的参考指标。
|
| 关 键 词： | 芬太尼 MDR1 C3435T 基因多态性 镇痛 |
Association between MDR1 C3435T genetic polymorphism and postoperative analgesia of fentanyl |
| |
| DENG Jie,LI Ming,WU Xiaozhi,CHEN Guozhong,SONG Hongtao.Association between MDR1 C3435T genetic polymorphism and postoperative analgesia of fentanyl[J].Chinese Journal of Clinical Pharmacy,2011(3):129-132. |
| |
| Authors: | DENG Jie LI Ming WU Xiaozhi CHEN Guozhong SONG Hongtao |
| |
| Institution: | DENG Jie~(1,2),LI Ming~3,WU Xiaozhi~3,CHEN Guozhong~3,SONG Hongtao~1(1 Department of Pharmacy,3 Department of Anesthesiology,Fuzhou General Hospital of Nanjing Military District,Fuzhou 350025,China,2 School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China) |
| |
| Abstract: | AIM To investigative the relationship between MDR1 C3435T genetic polymorphism and postoperative analgesia of fentanyl.METHODS The postoperative analgesic requirement of fentanyl and the adverse drug reactions happened were recorded after operation.Polymerase chain reaction-restriction fragment length polymorphism(PCRRFLP) was used to detect the polymorphism of MDR1 C3435T.The analgesic effect was compared among the several polymorphisms of MDR1 C3435T.RESULTS In 129 patients,51(39.5%),57(44.2%) and 21(16.3... |
| |
| Keywords: | fentanyl MDR1 C3435T genetic polymorphism analgesia |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
