| 癌痛的发生机制及其相关药物治疗的研究现状 |
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| 引用本文： | 王妙苗.癌痛的发生机制及其相关药物治疗的研究现状[J].临床肿瘤学杂志,2011,16(7):662-666. |
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| 作者姓名： | 王妙苗 |
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| 作者单位： | ２０００７０ 上海 第二军医大学附属长征医院肿瘤科 |
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| 摘 要： | 癌痛是一种机制独特而复杂的慢性疼痛,在动物模型中表现出对痛觉过敏、超敏等疼痛相关行为,其相应的脊髓节段内发生独特的神经化学改变.癌痛的发生与外周传入神经敏化和中枢敏化有关,在癌痛早期,以肿瘤细胞、炎症细胞产生的致痛物质以及破骨细胞的持续活化所致的初级传人神经敏化为主；在癌痛后期,肿瘤生长引起的神经压迫与损伤参与了癌痛的...
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| 关 键 词： | 癌痛 动物模型 机制 药物治疗 |
| 收稿时间： | 2010-11-08 |
| 修稿时间： | 2011-02-15 |
The update study of the initiation mechanism and drug therapies of cancer pain |
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| WANG Miao-miao.The update study of the initiation mechanism and drug therapies of cancer pain[J].Chinese Clinical Oncology,2011,16(7):662-666. |
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| Authors: | WANG Miao-miao |
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| Institution: | WANG Miao-miao,WANG Jie-jun.Department of Oncology,Changzheng Hospital,Second Military Medical University,Shanghai 200070,China |
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| Abstract: | Cancer pain is a unique and complex kind of chronic pain.The animal model of cancer pain shows hyperalgesia,hypersensitivity and pain-related behavior,and unique neurochemical changes occur in the corresponding spinal cord segment.Cancer pain is related to peripheral afferent sensitization and central sensitization.At the early stage of cancer pain,the tumor cells,inflammatory cells of induced pain substance,and the continued activation of osteoclasts induced sensitization of primary afferent-based.At the l... |
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| Keywords: | Cancer pain Animal model Mechanism Drug therapy |
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