| 响应面法优选妇科IV颗粒一步制粒工艺 |
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| 引用本文： | 刘丹,何凤军,刘长龙,刘俊超,吴云,王振中,萧伟.响应面法优选妇科IV颗粒一步制粒工艺[J].中国中药杂志,2016,41(1):75-82. |
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| 作者姓名： | 刘丹 何凤军 刘长龙 刘俊超 吴云 王振中 萧伟 |
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| 作者单位： | 江苏康缘药业股份有限公司, 江苏连云港 222001;中药制药过程新技术国家重点实验室, 江苏连云港 222001;中药提取精制新技术重点研究室, 江苏连云港 222001,江苏康缘药业股份有限公司, 江苏连云港 222001;中药制药过程新技术国家重点实验室, 江苏连云港 222001;中药提取精制新技术重点研究室, 江苏连云港 222001,江苏康缘药业股份有限公司, 江苏连云港 222001;中药制药过程新技术国家重点实验室, 江苏连云港 222001;中药提取精制新技术重点研究室, 江苏连云港 222001,江苏康缘药业股份有限公司, 江苏连云港 222001;中药制药过程新技术国家重点实验室, 江苏连云港 222001;中药提取精制新技术重点研究室, 江苏连云港 222001,江苏康缘药业股份有限公司, 江苏连云港 222001;中药制药过程新技术国家重点实验室, 江苏连云港 222001;中药提取精制新技术重点研究室, 江苏连云港 222001,江苏康缘药业股份有限公司, 江苏连云港 222001;中药制药过程新技术国家重点实验室, 江苏连云港 222001;中药提取精制新技术重点研究室, 江苏连云港 222001,江苏康缘药业股份有限公司, 江苏连云港 222001;中药制药过程新技术国家重点实验室, 江苏连云港 222001;中药提取精制新技术重点研究室, 江苏连云港 222001 |
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| 基金项目： | 国家"重大新药创制"科技重大专项(2013ZX09402203) |
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| 摘 要： | 利用响应面法优选妇科IV(FKIV)颗粒一步制粒的工艺条件。以颗粒合格率为指标,利用Plackett-Burman设计实验,对影响一步制粒的6个因素进行考察,评价各因素显著水平并确定主要影响因素。在此基础上,以颗粒合格率、含水量、休止角为指标,建立3因素3水平的Box-Behnken设计,对模型进行全二次回归拟合,并利用Response Optimizer优化实验结果。确定最佳一步制粒工艺条件:浸膏相对密度1.20,进风温度88℃,雾化压力0.28 MPa。利用该优化方案制备妇科IV颗粒,测得的颗粒合格率93.65%,含水量3.76%,休止角23.19°,与模型预测值基本一致,说明优化的工艺条件符合生产要求。
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| 关 键 词： | 妇科IV颗粒 响应面法 一步制粒 Plackett-Burman 设计 Box-Behnken设计 |
| 收稿时间： | 2015/6/16 0:00:00 |
Optimization of one-step pelletization technology of Fuke IV granules with response surface methodology |
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| LIU Dan,HE Feng-jun,LIU Chang-long,LIU Jun-chao,WU Yun,WANG Zhen-zhong and XIAO Wei.Optimization of one-step pelletization technology of Fuke IV granules with response surface methodology[J].China Journal of Chinese Materia Medica,2016,41(1):75-82. |
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| Authors: | LIU Dan HE Feng-jun LIU Chang-long LIU Jun-chao WU Yun WANG Zhen-zhong and XIAO Wei |
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| Institution: | Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of Pharmaceutical Process New-teach for Chinese Medicine, Lianyungang 222001, China;Key Laboratory for New Technique Research of Traditional Chinese Medicine Extraction and Purification, Lianyungang 222001, China,Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of Pharmaceutical Process New-teach for Chinese Medicine, Lianyungang 222001, China;Key Laboratory for New Technique Research of Traditional Chinese Medicine Extraction and Purification, Lianyungang 222001, China,Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of Pharmaceutical Process New-teach for Chinese Medicine, Lianyungang 222001, China;Key Laboratory for New Technique Research of Traditional Chinese Medicine Extraction and Purification, Lianyungang 222001, China,Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of Pharmaceutical Process New-teach for Chinese Medicine, Lianyungang 222001, China;Key Laboratory for New Technique Research of Traditional Chinese Medicine Extraction and Purification, Lianyungang 222001, China,Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of Pharmaceutical Process New-teach for Chinese Medicine, Lianyungang 222001, China;Key Laboratory for New Technique Research of Traditional Chinese Medicine Extraction and Purification, Lianyungang 222001, China,Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of Pharmaceutical Process New-teach for Chinese Medicine, Lianyungang 222001, China;Key Laboratory for New Technique Research of Traditional Chinese Medicine Extraction and Purification, Lianyungang 222001, China and Jiangsu Kanion Pharmaceutical Co., Ltd., Lianyungang 222001, China;State Key Laboratory of Pharmaceutical Process New-teach for Chinese Medicine, Lianyungang 222001, China;Key Laboratory for New Technique Research of Traditional Chinese Medicine Extraction and Purification, Lianyungang 222001, China |
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| Abstract: | |
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| Keywords: | Fuke IV granules response surface methodology one-step pelletization Plackett-Burman design Box-Behnken design |
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