| 地龙加桂枝茯苓丸干预脑梗死发病的临床研究 |
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| 引用本文： | 曲红,周蔓蔓,汪涛,陈磊,丁永生,钟萍,韩伏莅,吴丹红,吴坚,殷善叶. 地龙加桂枝茯苓丸干预脑梗死发病的临床研究[J]. 上海中医药杂志, 2009, 0(7): 15-19 |
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| 作者姓名： | 曲红 周蔓蔓 汪涛 陈磊 丁永生 钟萍 韩伏莅 吴丹红 吴坚 殷善叶 |
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| 作者单位： | 上海市中西医结合医院神经内科,上海,200082;上海中医药大学附属岳阳中西医结合医院神经内科,上海,200437;上海市江湾医院神经内科,上海,201900;上海交通大学附属第三人民医院神经内科,上海,200434;中国科学院上海生命科学院健康科学研究所,上海,200025 |
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| 基金项目： | 上海市自然科学基金项目(06ZR14151);;上海市卫生局资助项目(2005L020A) |
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| 摘 要： | 目的探讨以脑内微小病变为中风治未病的客观依据,观察中药干预脑梗死发病的效果。方法以120例头颅核磁共振成像（MRI）显示的基底节上部存在Ⅱ型（T1WI高信号,T2WI高信号,FLAIR等信号）和Ⅲ型（T1WI高信号,T2WI高信号,FLAIR低信号）的多发微小病变的病例为研究对象,随机分为中药治疗组（地龙加桂枝茯苓丸）、阿司匹林对照组和阴性对照组各40例;3个月为1个疗程,连续服药时间不少于3个月;随访各组脑梗死发病情况。结果120例研究对象平均随访（400.69±207.60）天,最长随访822d,至截点各组均无死亡病例;中药治疗组无脑梗死发病病例,其中4例复查头颅MRI,微小病变无变化;阿司匹林对照组脑梗死发病1例;阴性对照组脑梗死发病5例。中药治疗组与阴性对照组的发病率具有显著差异（P〈0.05）。结论中药可以控制脑内微小病变,进而预防脑梗死发生。
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| 关 键 词： | 脑梗死 预防与控制 脑内微小病变 中医药疗法 桂枝茯苓丸 地龙 |
Clinical Research on Pheretima and "Guizhi Fuling Pill" in Preventing Attack of Cerebral Infarction |
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| QU Hong ZHOU Man-man WANG Tao CHEN Lei DING Yong-shengZHONG Ping HAN Fu-li WU Dan-hong WU Jian YIN Shan-ye. Clinical Research on Pheretima and "Guizhi Fuling Pill" in Preventing Attack of Cerebral Infarction[J]. Shanghai Journal of Traditional Chinese Medicine, 2009, 0(7): 15-19 |
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| Authors: | QU Hong ZHOU Man-man WANG Tao CHEN Lei DING Yong-shengZHONG Ping HAN Fu-li WU Dan-hong WU Jian YIN Shan-ye |
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| Affiliation: | QU Hong1 ZHOU Man-man1 WANG Tao2 CHEN Lei2 DING Yong-sheng2ZHONG Ping1 HAN Fu-li3 WU Dan-hong4 WU Jian1 YIN Shan-ye51.Shanghai Hospital of Integrative Chinese , Western Medicine2.Yueyang Hospital of Integrative Chinese , Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine3.Jiangwan Hospital of Shanghai4.The Third Hospital Affiliated to Shanghai Jiaotong University5.Shanghai Life Institute,China Academy of Sciences |
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| Abstract: | Objective To observe the clinical efficacy of herbal medicines in intervening cerebral infarction. Methods 120 cases of cerebral infarction confirmed by MRI were randomized into three groups ： treatment group in which 40 cases were treated with pheretima and ＂Guizhi Fuling Pill＂, control group in which 40 cases were treated with Aspirin, and sham group in which 40 cases were given no treatment, with a course of three months. Results In the （ 558 ±215 ） -day follow-up, no death happened ; cerebral infarction did not develop in treatment group, 1 case of cerebral infarction in control group and 5 cases in sham group. There was a difference between treatment group and sham group in the incidence of cerebral infaretion（P 〈0.05 ）. Conclusion Herbal medicines can control intracerebral microlesion to prevent cerebral infarction. |
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| Keywords: | Cerebral infarction prevention and control intracerebral microlesion Chinese medicine " Guizhi Fuling Pill" pheretima |
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