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IgE-induced changes in human basophil cyclic AMP levels. |
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| Authors: | L M Lichtenstein A K Sobotka F J Malveaux E Gillespie |
| Abstract: | We studied a unique patient with 77% basophils, not different from normal by a number of criteria, in order to measure the changes in cyclic AMP level associated with IgE-mediated histamine release. In accordance with previous hypothesis and circumstantial evidence, anti-IgE challenge led to a significant fall in the cyclic AMP level which preceded histamine release. |
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