| 保康戒毒冲剂对吗啡依赖小鼠戒断症状抑制作用的实验研究 |
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| 引用本文： | 陆贤杰,覃园程,陈力力,刘元. 保康戒毒冲剂对吗啡依赖小鼠戒断症状抑制作用的实验研究[J]. 右江民族医学院学报, 1999, 0(2): 171-172 |
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| 作者姓名： | 陆贤杰 覃园程 陈力力 刘元 |
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| 作者单位： | 1. 右江民族医学院药物依赖研究所,百色,533000
2. 广西中医药研究所 |
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| 摘 要： | 采用递增剂量法（吗啡剂量从２５ｍｇ／ｋｇ开始，逐渐增至１５０ｍｇ／ｋｇ）皮下注射给药４天，形成小鼠戒断模型后，灌胃保康戒毒冲剂，剂量为４１０、８１９ｇ生药／ｋｇ·ｄ－１，分４次给药，连续３天。结果表明，给药组小鼠的跳跃次数明显少于对照组（Ｐ＜００５～００１），体重下降比生理盐水对照组轻，但无统计学意义（Ｐ＞００５）。说明“保康戒毒冲剂”对吗啡依赖小鼠的戒断症状有较好的抑制作用。药物效应与剂量有关。
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| 关 键 词： | 吗啡；中草药；物质禁断综合征；保康戒毒冲剂／药理学；药物量—效关系 |
A study of 'Bao Kang Jie Du Chong Ji' to precipitate the withdrawal syndromes on morphine-induced physical dependence in mice |
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| Lu Xianjie,Chen Yuancheng,Chen lili,Liu Yuan. A study of 'Bao Kang Jie Du Chong Ji' to precipitate the withdrawal syndromes on morphine-induced physical dependence in mice[J]. Journal of Youjiang Medical College For Nationalities, 1999, 0(2): 171-172 |
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| Authors: | Lu Xianjie Chen Yuancheng Chen lili Liu Yuan |
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| Affiliation: | Lu Xianjie Chen Yuancheng Chen lili Liu Yuan Youjiang Medical College for Nationalities,Baise,Guangxi,P.R.China 533000 |
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| Abstract: | The mouse dependence model was established by gradually increasing doses of morphine (from 25mg·kg -1 to 150mg·kg -1 , SC 4d ). Then Chinese herbal medicine (Bao Kang Jie Du Chong Ji) was given to precipitate the withdrawal syndromes. The results showed that in the dose of 41 0-81 9g (crude drug)/kg·d -1 were able to inhibit the jumping.There were significant difference between experimental group and control groups( P <0 05～0 01). It can be seen that 'Bao Kang Jie Du Chong Ji' could completely block morphine-induced physical dependence in mice. There was relationship between drug effect and doses. |
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| Keywords: | morphine chinese herbal medicine substance withdrawl syndrome bao kang jie du chong ji/pharmacology drug effect and doses |
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