Avoidance conditioning in rats following changes in activity of the noradrenergic and cholinergic systems of the brain |
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Authors: | N N Martynov O A Bessonova |
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Institution: | (1) Laboratory of Functional Neuromorphology, Institute of Physiology, Siberian Branch, Academy of Medical Sciences of the USSR, Novosibirsk |
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Abstract: | Bilateral coagulation of the ventral noradrenergic pathways of the brain in male rats of the Wistar strain disrupted the conditioned passive avoidance response after unconditioned stimulation with a current of 0.75 mA. Injecting 10 mg/kg galantamine into these rats 20 min before training and increasing the unconditioned stimulus to 3 mA improved subsequent avoidance responses. Injecting galantamine under analogous conditions into normal rats impaired this reaction. Disruption of the conditioned avoidance response following the operation may be due to a change in the intracentral interrelation of the noradrenergic and cholinergic systems of the brain.Translated from Fiziologicheskii Zhurnal SSSR imeni I. M. Sechenova, Vol. 68, No. 3, pp. 297–302, March, 1982. |
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Keywords: | ventral noradrenergic pathways noradrenergic and cholinergic systems of the brain conditioned reaction of passive avoidance |
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