血管紧张素转换酶基因多态性与脑血管病的关系

目的　探讨血管紧张素转换酶 (ACE)基因多态性与脑血管病的关系。方法　应用聚合酶链反应 (PCR)方法对 10 0例脑血管病患者 (脑血管病组 )和 10 0名健康体检者 (对照组 )进行ACE基因检测及基因多态性分析。结果　DD基因型频率脑出血组 (34 4 % )明显高于对照组 (16 .0 % ) (P <0 0 5 ) ;脑血管病合并原发性高血压组明显高于不合并原发性高血压组 (P <0 0 5 ) ;合并血糖异常组明显高于血糖正常组 (P <0 0 5 ) ;且伴血脂异常组DD基因型频率和D等位基因频率明显高于血脂正常组 (P <0 0 5 )。结论　DD基因型是脑出血患者的高危因素 ;DD基因型和D等位基因可能与脑血管病的高危因素如血糖、胆固醇、高密度脂蛋白水平等有一定的关系

Relationship between I/D polymorphism of ACE gene and cerebrovascular diseases

Objective To study the relationship between I/D polymorphism of ACE gene and cerebrovasular diseases.Methods I/D polymorphism of ACE gene was analysed in 100 cerebrovascular patients and 100 normal people by polymerase chain reaction (PCR).Results The frequency of DD genotype of angiotension-convertion enzyme (ACE) in cerebral hemorrhage group (34.4%) was significantly higher than that in control group (16.0%) ( P<0.05), and the frequency of DD genotype was higher in the patients of cerebrovasular disease with essential hypertension than the patients without essential hypertension ( P<0.05). It was also higher in the patients with glycemia than the patients with euglycemia ( P<0.05). Moreover, the frequency of DD genotype and D alleles in abnormity group were significantly higher than those in normal group of cholesterol and high-density lipoprotein ( P<0.05).Conclusions The DD genotype is the high risk factor of cerebral hemorrhage. DD genotype and D alleles are associataed with the high risk factors of cerebrovascular disease such as essential hypertension, blood sugar, cholesterol and high-density lipoprotein.