| 胰岛素受体底物-1/-2与胰岛素信号转导 |
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| 引用本文： | 舒适,宋菊敏.胰岛素受体底物-1/-2与胰岛素信号转导[J].医学综述,2008,14(5):723-725. |
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| 作者姓名： | 舒适 宋菊敏 |
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| 作者单位： | 上海中医药大学基础医学院实验中医学教研室,上海,201203 |
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| 摘 要： | 胰岛素受体底物(IRS)是胰岛素信号传递的重要介质,其中IRS-1和IRS-2在胰岛素信号转导通路中的作用尤为重要。IRS-1和IRS-2在体内多个组织中均有表达,其中在胰岛β细胞、肝脏、骨骼肌和脂肪组织中表达最为丰富。近年来国内外在对IRS-1和IRS-2的研究中发现,无论是糖尿病患者或是模型,其胰岛β细胞、肝脏、骨骼肌和脂肪组织中IRS-1和IRS-2的表达均有改变,且变化程度各有不同。
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| 关 键 词： | 胰岛素受体底物1 胰岛素受体底物2 胰岛素 信号转导 胰岛素抵抗 |
| 文章编号： | 1006-2084（2008）05-0723-03 |
| 收稿时间： | 2007-07-29 |
| 修稿时间： | 2007-10-11 |
Insulin Receptor Substrate-1/-2 and Insulin Resistance |
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| SHU Shi,SONG Ju-min.Insulin Receptor Substrate-1/-2 and Insulin Resistance[J].Medical Recapitulate,2008,14(5):723-725. |
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| Authors: | SHU Shi SONG Ju-min |
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| Institution: | SHU Shi,SONG Ju-min.(Department of Experimental Traditional Chinese Medicine,Foundation Medical College,Shanghai University of TCM,Shanghai 201203,China) |
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| Abstract: | IRS is an important medium in insulin signal transmission, and IRS-1 and IRS-2 are the two omost important ILLS. IRS-1 and IRS-2 express in many organizations of humanbody, especially in pancreatic beta ceils, liver, muscle and fat and etc. In recent years, the expressions of IRS-1 and IRS-2 were changed in pancreatic beta cells, liver, muscle and fat in different levels in both diabetes patients and models. |
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| Keywords: | Insulin receptar substrate-1 Insulin receptor substrate-2 insulin signal transmission Insulin resistance |
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