血管紧张素转化酶抑制剂致不良反应102例分析

目的 :通过对血管紧张素转化酶抑制剂 (ACEI)引起的不良反应的分析 ,提高对其不良反应的认识 ,以便更好地发挥ACEI的治疗作用。方法 :回顾分析住院患者应用ACEI治疗高血压、心力衰竭的临床疗效与不良反应 ,探讨ACEI引起不良反应的发生率及不良反应与不同ACEI药物之间的关系。结果 :(1)ACEI引起不良反应的发生率为12 % ,常见类型有刺激性咳嗽、味觉异常及胃肠道不适、皮疹及皮肤瘙痒、低血压、头痛及眩晕、蛋白尿与血管性水肿等。(2)比较的5种ACEI药物中 ,不良反应发生率最高的为卡托普利 ,且以咳嗽、味觉异常及胃肠道不适、皮疹及皮肤瘙痒最多。结论 :ACEI引起的不良反应以咳嗽、胃肠道不适及皮疹最常见 ,停药后可自行消失。

Clinical Analysis of 102 Cases of ARDs Induced by Angiotension Converting Enzyme Inhibitors

OBJECTIVE:To analysis the adverse reactions of angiotension converting enzyme inhibitor(ACEI),so as to deepen the understanding to the ARDs and improve the therapeutic effect of ACEI METHODS:The therapeutic effects and ARDs of ACEI were retrospectively reviewed and the incidence of ARDs induced by ACEI and the relationship between different ACEIs and their ARDs were analyzed RESULTS:(1)The incidence of ARDs of ACEI was 12% Stimulating cough,parageusia,gastrointestinal tract discomfort,skin rash,itch of skin,hypotension,headache,dizziness,proteinuria and angioedema were the common symptoms (2)Of five kinds of ACEIs,captopril induced the highest incidence of ARDs and stimulating cough,parageusia,gastrointestinal tract discomfort,skin rash and itch of skin were the most common manifestations CONCLUSION:Stimulating cough,parageusia,gastrointestinal tract discomfort and skin rash are the most common symptoms of ARDs,and the symptoms will disappear when drug administration is discontinued