HPLC法测定咳特灵糖浆中马来酸氯苯那敏的含量及含量均匀度 |
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引用本文: | 江溱. HPLC法测定咳特灵糖浆中马来酸氯苯那敏的含量及含量均匀度[J]. 中国民族民间医药杂志, 2011, 20(18): 50-51 |
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作者姓名: | 江溱 |
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作者单位: | 广西古方药业有限公司; |
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摘 要: | 目的:建立用HPLC法测定咳特灵糖浆中马来酸氯苯那敏的含量及含量均匀度的方法。方法:色谱柱为Kromasil柱C18(4.6×250mm,5μm);流动相为乙腈-0.35%磷酸-0.35%三乙胺溶液(11:89),流速为1.0ml/min,检测波长为264nm,进样量为10山;柱温为室温。结果:以对照品进样浓度为横坐标(x),峰积积分值为纵坐标(Y)绘制标准曲线,回归方程为:Y=5973.6X-3462.8,相关系数r=0.9992。线性范围为在20.0~70.0μg/ml。结论:该方法简便、准确,可用于咳特灵糖浆中的马来酸氯苯那敏的质量控制。
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关 键 词: | 马来酸氯苯那敏 咳特灵糖浆 HPLC 含量均匀度 |
Determination of Content and Content Uniformity of ChlorPhenamine maleate in Suganning Capsules by HPLC |
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Abstract: | Objective: To establish method for determining the content and uniformity of ChlorPhenamine maleate in Keteling syrup by HPLC. Methods: The Kromasil -C18 (4. 6×250mm, 5μm) was used and mobile phase was acetonitrile -0. 35% Phosphoric acid-0. 35% triethylamine (11: 89), and its temperature was used at room temperature, with the flow rate of 1.0ml/min and the wavelength of detection of 262 nm, and the injection amount of 10μ1. Results: Chlorphenamine maleat showed a good linear relation- ship in the range of 20. 0 -70. 0μg/ml, Y = 1.06×105X +29014. 3, r =0. 9995. Conclusions: The method is simple, accurate, and can be used to determine the content assaying of ChlorPhenamine maleate in Keteling syrup. |
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Keywords: | Chlorpheniramine maleate Keteling syrup HPLC content uniformity |
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