Increased serotonin platelet uptake after tianeptine administration in depressed patients |
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Authors: | G Chamba P Lemoine E Flachaire N Ferry C Quincy J Sassard C Ferber E Moca?r A Kamoun B Renaud |
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Affiliation: | Laboratoire de Neuropharmacologie, Université Claude Bernard, Lyon, France. |
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Abstract: | Tianeptine is a new antidepressant drug reported to enhance serotonin (5-hydroxytryptamine [5-HT]) uptake in rat brain. The effect of tianeptine on 5-HT platelet uptake was studied in 10 depressed patients treated for 28 days. Tianeptine increases Vmax of 5-HT platelet uptake during treatment without inducing any change in Km. As early as 2 hr after the first administration, Vmax increased significantly (+23%, alpha = 0.01). Although of a lesser magnitude, 5-HT platelet uptake remains increased after chronic administration (+14% on day 10 and +13% on day 28). This suggests that tianeptine affects 5-HT platelet uptake sites, either directly or via an action on modulators of 5-HT uptake. These results, in contrast with the action of other tricyclic antidepressants, confirm the original action of tianeptine on 5-HT platelet metabolism. |
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