| 血管内皮生长因子在骨折伴颅脑损伤患者血清中的表达 |
| |
| 引用本文： | 陈涛,尚希福,李旭,贺瑞,胡飞,葛畅.血管内皮生长因子在骨折伴颅脑损伤患者血清中的表达[J].国际骨科学杂志,2011(5). |
| |
| 作者姓名： | 陈涛 尚希福 李旭 贺瑞 胡飞 葛畅 |
| |
| 作者单位： | 安徽医科大学附属省立医院骨二科; |
| |
| 摘 要： | 目的探讨骨折伴颅脑损伤患者血清中血管内皮生长因子(VEGF)与骨折愈合的关系。方法收集我院2008年9月至2010年9月期间收治的骨折患者40例,分为骨折伴颅脑损伤组及单纯骨折组,每组各20例。采用双抗体夹心酶联免疫吸附试验(ELISA)测定所有患者血清中VEGF水平,并摄X线片观察骨痂出现及骨折愈合情况,分析VEGF水平变化及骨折愈合过程。结果骨折伴颅脑损伤患者血清中VEGF含量在7d左右出现高峰期(519±44ng/ml),维持较高水平至42d,以后逐渐下降;单纯骨折患者血清中VEGF含量在14d左右为高峰期(438±28ng/ml),28d左右开始逐渐下降。骨折伴颅脑损伤患者骨痂形成时间(8d±0.3d)明显早于单纯骨折患者(18d±0.1d),P<0.01;骨折伴颅腑损伤患者骨折愈合时间(42d±0.4d)明显早于单纯骨折患者(84d±0.2d),P<0.01。结论骨折伴颅脑损伤患者血清中VEGF含量明显高于单纯骨折患者,骨痂形成及骨折愈合时间均比单纯骨折患者所需时间短。颅脑损伤患者VEGF升高可能是骨折愈合加快的原因之一。
|
| 关 键 词： | 血管内皮生长因子 颅脑损伤 骨折愈合 |
Expression of vascular endothelial growth factor in blood serum of fracture patients with brain injury |
| |
| CHEN Tao,SHANG Xi-fu,LI Xu,HE Rui,HU Fei,GE Chang.Expression of vascular endothelial growth factor in blood serum of fracture patients with brain injury[J].International Journal of Orthopaedics,2011(5). |
| |
| Authors: | CHEN Tao SHANG Xi-fu LI Xu HE Rui HU Fei GE Chang |
| |
| Institution: | CHEN Tao,SHANG Xi-fu,LI Xu,HE Rui,HU Fei,GE Chang.Department of Orthopaedics,Anhui Provincial Hospital Affiliated to Anhui Medical University,Hefei 230001,China |
| |
| Abstract: | Objective To study the relationship between serum vascular endothelial growth factor(VEGF) and fracture healing in fracture patients with brain injury.Methods Forty fracture patients were enrolled in the study,including 20 fracture patients with brain injury and 20 simple fracture patients.The patients' serum VEGF was examined by enzyme-linked immunosorbent assay(ELISA).The bone callus and the fracture healing were observed on X-Ray film.The VEGF level and process of fracture healing were analyzed.Results T... |
| |
| Keywords: | Vascular endothelial growth factor Brain injury Fracture healing |
| 本文献已被 CNKI 等数据库收录！ |
|
