| 应用纤维蛋白靶向对比剂对兔大脑中动脉红色和白色栓子的MRI分子影像学评价 |
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| 引用本文： | 王志红,刘怀军,郝冀洪,徐英进,宋利宏,田泽君,赵林,贺丹. 应用纤维蛋白靶向对比剂对兔大脑中动脉红色和白色栓子的MRI分子影像学评价[J]. 脑与神经疾病杂志, 2009, 17(4): 245-248 |
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| 作者姓名： | 王志红 刘怀军 郝冀洪 徐英进 宋利宏 田泽君 赵林 贺丹 |
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| 作者单位： | 河北医科大学第二医院神经内科,石家庄,050000;河北医科大学第二医院医学影像科,石家庄,050000;河北医科大学第二医院检验科,石家庄,050000;河北医科大学第二医院心脏内科,石家庄,050000 |
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| 基金项目： | 河北省自然基金资助项目 |
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| 摘 要： | 目的进行纤维蛋白靶向对比剂对兔大脑中动脉红色或白色栓子的MRI分子影像学评价。方法血红色和白色栓子在24小时前制作。在透视下将3F微导管插入左颈内动脉近心端,将放在2ml生理盐水中的2个红色或白色栓子在3～5min内缓慢注入颈内动脉。于注射EP-2104R或Magnevist前及注射后进行连续T1-FLAIR和T1加权双翻转快速自旋回波序列血栓分子磁共振成像。结果在对比剂EP2104R注射之前,无论红色、还是白色栓子均未显示。在注射EP2104R后,红色和白色栓子均能够准确显示,呈亮点,与周围组织形成对比。在Gd-DTPA对照组动物,栓子注射后,注射Gd-DTPA后6个小时,没有任何对比作用,栓子未显示增强改变。结论应用纤维蛋白靶向对比剂EP-2104R能够选择性的显示兔大脑中动脉红色和白色栓子。
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| 关 键 词： | 兔 栓子 磁共振成像 分子影像学 EP-2104R |
Molecular magnetic resonance imaging of red and white emboli in middle cerebral artery with EP-2104R in rabbits |
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| WANG Zhi-hong,LIU Huai-jun,HAO Ji-hong,XU Ying-jin,SONG Li-hong,TIAN Ze-jun,ZHAO Lin,HE Dan. Molecular magnetic resonance imaging of red and white emboli in middle cerebral artery with EP-2104R in rabbits[J]. Journal of Brain and Nervous Diseases, 2009, 17(4): 245-248 |
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| Authors: | WANG Zhi-hong LIU Huai-jun HAO Ji-hong XU Ying-jin SONG Li-hong TIAN Ze-jun ZHAO Lin HE Dan |
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| Affiliation: | WANG Zhi-hong,LIU Huai-jun,HAO Ji-hong,XU Ying-jin,SONG Li-hong,TIAN Ze-jun,ZHAO Lin,HE Dan.Department of Neurology,the Second Hospital of Hebei Medical University,Shijiazhuang 050000,China |
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| Abstract: | Objective In the present study,we attempted to evaluate the application of EP-2104R into molecular magnetic resonance imaging of red and white emboli in the MCA in rabbits.Methods The red and white emboli was engineered ex vivo from human blood approximately 24 hours previously.Under angiography,a 3F catheter was advanced into the proximal part of the left internal carotid artery(ICA).Subsequent molecular MR imaging was performed with T1-FLAIR and T1-weighted double-inversion recovery(DIR)fast spin echo seq... |
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| Keywords: | EP-2104R |
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