骨组织工程材料的表面仿生矿化

骨组织工程材料的表面特性与体内组织直接接触,对材料与细胞组织间的相互作用情况起关键作用,因而对植入体内材料的表面进行改性就显得特别重要。在材料表面制备生物矿化层能够提高材料的生物相容性和细胞亲和性。仿生矿化是根据仿生原理制备合成复合人工材料的新方法。本文就近年来有关仿生矿化的机理和用于诱导仿生矿化的骨组织工程支架基质材料的研究进展进行了综述。

Biomimetic mineralization of scaffold materials for bone tissue engingeering

It is important for an orthopaedic implant to exhibit a bone bonding behaviour.An essential condition for a material to bond to living bone is the formation of a biologically active bone-like mineral layer on its surface as a natural bonding junction between living bone and non-living biomaterials.Biomimetic mineraliza-tion is a new methodology to produce bioactive coatings on the surface of biomaterials.The present review focuses on late published advance in theory on biomimetic mineralization and biomaterials as matrices for biomimetic min eralization.[