脓毒症诊断和预后的生物标志物研究进展

脓毒症在重症监护病房（ICU）是一种常见且严重的并发症。近年来逐渐提出了许多脓毒症生物标志物,如C反应蛋白（CRP）、降钙素原（PCT）、细胞因子和血凝系统标志物等,这些脓毒症标志物可有效地排除脓毒症,但任何一种标志物都不能单独特异性诊断脓毒症。因此结合多种生物标志物检测结果来诊断脓毒症可以提高诊断效率。除此之外,一些生物标志物还可以用来判断预后和指导治疗。本文对与脓毒症的诊断和预后相关的生物标志物发展作一综述。

Research progress for diagnostic and prognostic biomarkers in sepsis

Sepsis is a frequent and serious complication in intensive care unit. Biological laboratory markers（biomarkers） have been used recently, ranging from the relatively simple C-reactive protein（CRP） to more complex biomarkers, such as procalcitonin（PCT）, cytokine levels and coagulation markers, all of these markers are more helpful at ruling out than at ruling in an infection, but none is specific enough to definitively determine diagnosis alone.Therefore, the combination of multiple biomarkers can improve the efficiency of diagnosis. Some biomarkers may also be useful for prognosis and guiding therapy. Here, we summarize the development of sepsis biomarker related to the diagnosis and prognosis of sepsis.