丹参注射液对脑梗塞急性期NO、ET的影响

目的 :观察丹参注射液对脑梗塞急性期血浆中一氧化氮 (NO)、内皮素 (ET)的影响。方法 :将 72例急性脑梗塞患者随机分为治疗组和对照组进行血浆 NO、ET的动态观察。结果 :在发病 72小时内 ,脑梗塞组血浆 ET明显升高 ,NO明显下降 ,与正常组比较 P均 <0 .0 1 ;治疗后两组 ET均有明显下降 (P<0 .0 1 ) ,NO有明显升高 (P<0 .0 1 ) ,但治疗组 ET降低 ,NO升高均较对照组显著(P<0 .0 5)。结论 :脑梗塞急性期应用活血化瘀中药有助于改善梗塞灶局部的血液供应 ,有助于抢救梗塞灶的半暗带

Effects of Danshen Injection on NO and ET Levels in Patients with Cerebral Infarction

To observe the effects of Danshen Injection on serum levels of NO and ET in patients with acute cerebral infarction.Methods:72 cerebral infarction cases were divided at random into two groups:Danshen group and control group so as to to detect the changes of NO and ET dynamically.Results:Within 72 hours of the onsetof the cerebral infarction,ET was significantly raised when compared with the normal cases (P<0 .0 1 ) while NO was significantly lowered compared with the normal cases in the control group(P<0 .0 1 ) .1 5days after the treatment ET was significantly lowered but NO wassignificantly raised compared with the onsetof the cerebral infarction (P<0 .0 1 ) .Difference was also observed in the ET decrease and NO increase between the two groups1 5daysafterthe treatment(P<0 .0 5) .Conclusions:Danshen injection was effectivein the treatm ent of acute cerebral infarction by im proving the blood supply of the infarcted area.