| 含照射与纯化疗的移植预处理方案治疗儿童白血病：Meta分析 |
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| 引用本文： | 徐世侠,汤先华,陈海青,冯博,徐海琴,陈效培,唐湘凤. 含照射与纯化疗的移植预处理方案治疗儿童白血病：Meta分析[J]. 海军总医院学报, 2008, 21(4): 212-215 |
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| 作者姓名： | 徐世侠 汤先华 陈海青 冯博 徐海琴 陈效培 唐湘凤 |
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| 作者单位： | 1. 海军总医院信息科,北京,100037
2. 海军总医院儿科,北京,100037 |
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| 摘 要： | 目的观察含照射与纯化疗的两种不同的移植预处理方案对儿童造血干细胞移植的治疗效果。方法计算机检索循证医学数据库、美国国立医学图书馆医学文献分析和联机检索系统、中国学术期刊网全文数据库、中国生物医学文献光盘数据库在199042007年期间发表的关于儿童白血液病移植中对比不同预处理方案的研究文献。从干细胞植入、移植后的治疗相关病死率、长期生存率等方面进行对比分析。采用Review Manager软件进行Meta分析。结果检索出4012篇文献，最终纳入9个试验共2333例患者。全身照射加环磷酰胺与白消安加环磷酰胺组相比植入失败率和移植后的复发率无明显区别：白消安加环磷酰胺组治疗相关病死率明显升高，而全身照射加环磷酰胺组长期无病生存率则明显优于白消安加环磷酰胺组。结论目前有限文献表明，全身照射加环磷酰胺预处理方案是儿童白血病移植的有效方案，而全身照射对儿童生长发育的长期不良影响有待进一步探讨。
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| 关 键 词： | 预处理 造血干细胞移植 META分析 白血病 儿童 |
Comparison of Total Body Irradiation(TBI) with Cyclophosphamide Versus Bulsulphan withCyclophosphamide as Conditioning for Children with Leukemia Disease:A Meta-Analysis |
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| XU Shi-xia,TANG Xian-hua,CHEN Hai-qing,FENG Bo,XU Hai-qin,CHEN Xiao-pei,TANG Xiang-feng. Comparison of Total Body Irradiation(TBI) with Cyclophosphamide Versus Bulsulphan withCyclophosphamide as Conditioning for Children with Leukemia Disease:A Meta-Analysis[J]. Journal of Naval General Hospital of PLA, 2008, 21(4): 212-215 |
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| Authors: | XU Shi-xia TANG Xian-hua CHEN Hai-qing FENG Bo XU Hai-qin CHEN Xiao-pei TANG Xiang-feng |
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| Affiliation: | XU Shi-xia1,TANG Xian-hua1,CHEN Hai-qing1,FENG Bo1,XU Hai-qin1,CHEN Xiao-pei1,TANG Xiang-feng2(1.Department of Information,Naval General Hospital,Beijing 100037,China,2.Department of Pediatrics,China) |
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| Abstract: | Objective This study is to compare the therapeutic efficacy of total body irradiation with cyclophosphamide(TBI/CY) versus bulsulphan with cyclophosphamide(BU/CY) as conditioning for children with leukemia disease.TBI/CY and BU/CY are standard condition regimens in hematological stem cell transplantation.Methods We electronically searched the Cochrane,MEDLINE,CNKI,Chinese Bio-medicine Database(CBM)and critica-lly appraised all relevant articles(1999-2007).Comparative studies were carried out on clinical the... |
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| Keywords: | Condition regimen Transplant Meta-analysis Leukemia Children |
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