电镜检查在肾活检标本病理诊断中的作用

目的客观评估电镜检查在肾活检标本病理诊断中的作用。方法对北京医科大学第一医院肾内科１９９５年１月～１９９７年６月的７７７例肾活检病例进行光镜和免疫荧光和电镜检查,并将光镜和免疫荧光检查的初步诊断与电镜检查最终诊断结果进行分析比较,从电镜检查在病理诊断中起决定性诊断作用、重要参考作用或与光镜检查相互补作用三方面进行了总结研究。结果７７７例肾活检病例中,电镜检查起决定性或修正诊断作用的病例占１８．５％,起重要参考作用或部分修正作用的病例占１３．５％。结论电镜检查对约１／３的肾活检病例的病理诊断提供了有价值的依据

The evaluation of electron microscopy in the pathological diagnosis of renal biopsies

OBJECTIVE: To evaluate the use of electron microscopy(EM) in pathological diagnosis of renal biopsies. METHOD: 777 cases of renal biopsy in Department of Nephrology, First Hospital of Beijing Medical University from Jan 1995 to Jun 1997 were studied. We compared the preliminary diagnosis by light microscopy(LM) and immuno-fluorescence(IF) with the final diagnosis by electron microscopy(EM). The use of EM in the diagnosis was divided into three parts. EM was needed to make a correct final diagnosis, provided confirmatory data or additional information relevant to the diagnosis and was complementary to LM and IF. RESULTS: Among 777 cases of renal biopsy, EM was needed to make a correct final diagnosis in 18.5%, and provided important referential information in 13.5%. CONCLUSION: EM provided useful diagnostic information in about one third cases of renal biopsy.