| The role of cell surface β1， 4－galactosyltransferase duringectoplacentacone outgrowth on laminin |
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| 引用本文： | 张春雨,段恩奎,曹宇靖,曾国庆,张春雨,曹宇靖,段恩奎,曾国庆.The role of cell surface β1， 4－galactosyltransferase duringectoplacentacone outgrowth on laminin[J].生殖医学杂志,1996(Z1). |
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| 作者姓名： | 张春雨 段恩奎 曹宇靖 曾国庆 张春雨 曹宇靖 段恩奎 曾国庆 |
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| 作者单位： | Zhang Chunyu ( 张春雨 )，Cao Yujing ( 曹宇靖 )，Duan Enkui (段恩奎)，Zeng Guoqing ( 曾国庆) |
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| 摘 要： | Ｔｈｅｒｏｌｅｏｆｃｅｌｌｓｕｒｆａｃｅβ１，４－ｇａｌａｃｔｏｓｙｌｔｒａｎｓｆｅｒａｓｅｄｕｒｉｎｇｅｃｔｏｐｌａｃｅｎｔａｃｏｎｅｏｕｔｇｒｏｗｔｈ ｏｎ ｌａｍｉｎｉｎＺｈａｎｇＣｈｕｎｙｕ（张春雨），ＣａｏＹｕｊｉｎｇ（曹宇靖），ＤｕａｎＥ...
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| 关 键 词： | Ectoplacental cone β1 4-galactosyltransferase Attachment Outgrowth Migration |
Therole of ell surfaceβ1 ,4-galactosyltransferase during ectoplacentacone outgrowth on laminin |
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| Zhang Chunyu.Therole of ell surfaceβ1 ,4-galactosyltransferase during ectoplacentacone outgrowth on laminin[J].Journal of Reproductive Medicine,1996(Z1). |
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| Authors: | Zhang Chunyu |
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| Abstract: | Mouse embryo implantation involves the invasion of the secondary trophoblast giantcells (STGCs) of the ectoplacental cone (EPCi into the uterine decidua , which deposits an extracellularinatrix (ECM) with abundant amounts of laminin (LN) in response to.implanting embryo. We inter-fered trophoblastic cell surface β1 , 4-galactosyltransferase (GalTasel binding to its N-acetylglucosamine(GlcNAc) residues associated with laminin oligosaccharides with a-lactalbumin, antibovine milk Gal-Tase, GlcNAc and pregalactosylation of LN, and found that these perturbations of the enzyme :sub-strate complex had no effect on EPC attachment , while prevented EPC outgrowth and STGCs migrationfrom EPC. The results indicated that GalTase mediates EPC outgrowth and STGCs migration, al-though doesn’t involve in the initial attachment of EPC on LN. |
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| Keywords: | Ectoplacental cone β1 4-galactosyltransferase Attachment Outgrowth Migration |
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