冠心病患者D-二聚体、血小板膜糖蛋白测定及临床意义

目的探讨冠心病（CHD）患者血中D-二聚体（D—dimer）、血小板膜糖蛋白（GP）的变化以及临床意义。方法分别测定20例稳定性心绞痛（SA）患者、48例不稳定性心绞痛（UA）患者、20例正常对照组体内的D—dimer、GP含量,并分析有无冠状动脉事件发生者之间的关系,以及与冠状动脉事件检出的敏感度。结果UA组D—dimer、GP含量与SA组、对照组相比较差异有统计学意义（P〈0．01）,而SA组与对照组相比均无统计学意义（均P〉0．05）。有冠状动脉事件发生者与无冠状动脉事件发生者相比也有统计学意义（P〈0．05）,D—dimer、GPⅡb、GPⅢa对冠状动脉事件的检出均较为敏感。结论D—dimer、GPⅡb、GPⅢa可作为冠状动脉血栓形成的指标之一,并在一定程度上反映了冠状动脉事件发生的危险性。

The changes and their clinical significance of D-dimer and platelet glycoprotein in patients with coronary heart disease

OBJECTIVE: To explore the changes and their clinical significance of D-dimer and platelet glycoprotein (GP) in patients with coronary heart disease. METHODS: D-dimer and GP in 20 patients with stable angina (SA group), 48 patients with unstable angina (UA group), and 20 control cases were measured. The changes of D-dimer and GP in patients with and without coronary events were compared. The sensitivity of those changes in the diagnosis of coronary events was evaluated. RESULTS: There were significant differences of D-dimer and GP between UA group and SA group or control group (P < 0.01), while there was no significant difference between SA group and control group (P > 0.05). There were also significant differences of D-dimer and GP between patients with coronary events and patients without coronary events (P < 0.05). In the sensitivity test for detecting coronary events, D-dimer and GPIIb, GPIIIa were much more sensitive than other parameters. CONCLUSIONS: D-dimer and GPIIb, GPIIIa may be regarded as the indexes of coronary thrombosis and used for predicting the severity of coronary events.