| 吉西他滨联合顺铂治疗晚期非小细胞肺癌的临床疗效观察 |
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| 引用本文： | 黄朝刚,刘海龙,雷恒,蔡翔. 吉西他滨联合顺铂治疗晚期非小细胞肺癌的临床疗效观察[J]. 中国医疗前沿, 2008, 3(13) |
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| 作者姓名： | 黄朝刚 刘海龙 雷恒 蔡翔 |
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| 作者单位： | 郴州市第一人民医院 |
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| 摘 要： | 目的观察吉西他滨加顺铂联合化疗治疗非小细胞肺癌(non-small cell lungcancer.NSCLC)的近期疗效及毒副作用。方法78例Ⅲ～Ⅳ期NSCLC患者,采用国产吉西他滨(泽菲)1000mg/m2,静滴,d1、d8;顺铂80mg/m2,静滴,d1,联合化疗。结果78例中CR+PR30例,有效率38.5%,主要毒副作用为骨髓抑制,其中Ⅲ、Ⅳ度中性粒细胞减少发生率为20.5%,Ⅲ、Ⅳ度血小板减少的发生率29.5%。非血液学毒性皆轻度并可耐受。结论吉西他滨联合顺铂方案治疗非小细胞肺癌疗效确切,毒副反应较轻,病人容易耐受,值得临床进一步使用观察。
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| 关 键 词： | 吉西他滨 顺铂 非小细胞肺癌 联合化疗 |
CLINICAL OBSERVATION ON ADJUVANT THERAPY WITH FORGEMCITABINE AND CISPLATIN FOR ADVANCED NON-SMALL CELL LUNG CANCER |
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| Huang chao-gang,Liu ha-ilong,Lei heng,Cai xiang. CLINICAL OBSERVATION ON ADJUVANT THERAPY WITH FORGEMCITABINE AND CISPLATIN FOR ADVANCED NON-SMALL CELL LUNG CANCER[J]. China Healthcare Innovation, 2008, 3(13) |
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| Authors: | Huang chao-gang Liu ha-ilong Lei heng Cai xiang |
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| Affiliation: | Huangchaogang Liuhailong; Leiheng. Caixiang The Frist People s Hospital of Chenzhou; Chenzhou 423000 China; |
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| Abstract: | Objective Observation gemcitabine plus cisplatin combination chemotherapy for non-small cell lung cancer (NSCLC) the efficacy and toxicity . Methods 78 cases of stage III-IV NSCLC patients, using homemade gemcitabine (Zefei) 1000mg/m2, intravenous, d1, d8; cisplatin 80mg/m2, intravenous, d1, combined with chemotherapy. Results It showed that CR+PR 30 ,and overall response rate was38.5 %. The main side effects included myelosuppression, There are grade Ⅲ-Ⅳoccured in 20.5 % and 29.5% of the patients respectiv... |
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| Keywords: | gemcitabine cisplatin advanced non-small cell lung cancer combined chemotherapy |
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