| 多巴反应性肌张力障碍临床资料分析 |
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| 引用本文： | 王雪贞,薛峥,孙昌兰,方思羽. 多巴反应性肌张力障碍临床资料分析[J]. 神经损伤与功能重建, 2007, 2(4): 224-226 |
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| 作者姓名： | 王雪贞 薛峥 孙昌兰 方思羽 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院神经内科,武汉,430030;华中科技大学同济医学院附属同济医院神经内科,武汉,430030;华中科技大学同济医学院附属同济医院神经内科,武汉,430030;华中科技大学同济医学院附属同济医院神经内科,武汉,430030 |
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| 摘 要： | 目的:回顾多巴反应性肌张力障碍(dopa-responsive dystonia,DRD)的临床资料,以加深对该病的认识。方法:总结并分析4例DRD患者的临床表现、辅助检查及治疗情况。结果:小剂量多巴制剂(美多巴62.5 mg,每天3次)对4例患者均有明显疗效。结论:DRD是一种较为罕见的遗传性运动障碍疾病,小剂量多巴制剂有显著、持续疗效,早期治疗效果好,需与其他肌张力障碍相鉴别,以震颤首发时易误诊为少年型帕金森病。
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| 关 键 词： | 多巴反应性肌张力障碍 临床特点 鉴别诊断 少年型帕金森病 |
| 文章编号： | 1001-117X（2007）04-0224-03 |
| 修稿时间： | 2007-05-29 |
Clinical Analysis of 4 patients with Dopa-responsive Dystonia |
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| WANG Xue-zhen,XUE Zheng,SUN Chang-lan,FANG Si-yu. Clinical Analysis of 4 patients with Dopa-responsive Dystonia[J]. Neural Injury and Functional Reconstruction, 2007, 2(4): 224-226 |
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| Authors: | WANG Xue-zhen XUE Zheng SUN Chang-lan FANG Si-yu |
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| Affiliation: | Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong Univercity of Science and Technology, Wuhan 430030, China |
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| Abstract: | Objective:The clinical data of dopa-responsive dystonia(DRD) has been reviewed.Methods: Clinical manifestation and therapy of 4 patients with DRD have been summarized.Results: Four patients with DRD were well responsive to small doses of dopa-preparation(6.25 mg of madopar three times a day).Conclusion: As an infrequently inherited motor disorder,DRD must be differentiated from other motor diseases,such as juvenile Parkinsonism who presents with tremor first.The disorder responds well to small doses of dopa-preparation in earlier period of course. |
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| Keywords: | dopa-responsive dystonia clinical manifestation differential diagnosis juvenile parkinsonism |
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