新疆维吾尔族支气管哮喘患者123例血清嗜酸细胞阳离子蛋白水平研究

目的探讨新疆维吾尔族人群血清嗜酸细胞阳离子蛋白(ECP)与支气管哮喘发病的关系。方法2004-05共调查212名新疆和田地区维吾尔族人。其中支气管哮喘123例,根据临床特点、肺功能(FEV1占预计值%)和所需药物情况将患者分为间歇发作(30例)、轻度(30例)、中度(32例)、重度(31例)4个组,年龄(38.35±9.17)岁。健康成年人89名,年龄(38.12±8.23)岁,作为正常对照组。血清ECP(S-ECP)水平测定由固定资深专业测试人员应用UniCAP100全自动体外变应原检测系统进行测定。结果S-ECP与哮喘的症状评分、1秒用力呼气容积(FEV1)和最大峰流速(PEF)高度相关(P<0.01)。在哮喘各组之间,S-ECP差异均有显著性意义(均P<0.01),最高值在重度哮喘患者组[ECP=(15.21±1.12)μg/L]出现,且S-ECP水平与病情严重程度呈正相关关系(r=0.63,P<0.01)。变态反应的出现与S-ECP值增高有关。S-ECP值与哮喘发作的自觉症状和通过检查所得的客观体征具有高度相关性,ECP与PEF之间存在负相关关系(r=-0.67,P<0.05)。结论S-ECP主要取决于嗜酸粒细胞激活程度和分泌蛋白的能力,它们能反映哮喘气道炎症的活动情况,并可预示哮喘发作的严重程度。

Study on the serum level of ECP in patients with bronchial asthma in Uygur population

Objective To explore serum ECP level of Xinjiang Uygur population and study the correlation of ECP with bronchial asthma,as well as their clinical significance in asthmatic patients in different degrees,so as to elucidate the role of ECP in the pathogenesis of bronchial asthma.Methods Between 2004 and 2005,123 Uygur asthmatics and 89 normal healthy controls with the same ethnic near Xinjiang Hetian region were investigated.The serum ECP were detected using a pharmarcia UniCAP 100 type instrument,pulmonary ventilatory function assessed by FEV_1 and PEF.Results Our data showed that the levels of S-ECP in moderate to severe asthma patients were significantly higher than in mild subjects and control group(P<0.01),the highest value being found in the severe asthma group.A significant correlation between S-ECP and symptom score were observed among participants(P<0.01).S-ECP had an additive value in predicting the occurrence of asthma.Furthermore,S-ECP showed good correlation with subjective and objective measures of asthma activity while there was negative correlation between S-ECP and PEF.Conclusion ECP can be an inflammatory mediator;S-ECP may be of value in assessing the activity of asthma.They might participate in the exacerbation of asthma.They can become effective means of monitoring the severity of disease and conducting anti-inflammation.