生脉注射液改善缓解期慢性肺源性心脏病患者心肺功能

目的评价生脉注射液对慢性阻塞性肺疾病合并慢性肺源性心脏病患者心肺功能的影响。方法慢性阻塞性肺疾病稳定期合并慢性肺源性心脏病代偿期患者106例,随机分为生脉组(50例)和对照组(56例),对照组按常规进行康复治疗同时加强营养支持,生脉组在常规康复治疗的基础上予生脉注射液60 ml加入5%葡萄糖注射液500 ml中静脉滴注,1次/d,共28 d。在治疗前后对患者进行肺通气功能、血气分析、超声心动图检查,并测试患者6 min步行距离(6MWD)。结果在治疗前两组患者的FEV1、FEV1/FVC、PaO2、SaO2、PaCO2无显著性差异,治疗后两组患者FEV1、FEV1/FVC、PaO2、SaO2、6MWD等指标均有不同程度改善(P<0.05),生脉组的改善程度优于对照组(P<0.05)。生脉组部分患者治疗后右心室流出道和右心室内径增宽有所改善,而对照组治疗前后右心室流出道和右心室内径无显著变化。结论生脉注射液能够改善慢性阻塞性肺疾病合并慢性肺源性心脏病患者的心肺功能,提高患者的运动耐受能力。

Shengmai injection improves the cardiorespiratory function of catabasis of chronic cor pulmonale patients

Objective To evaluate the effect of Shengmai injection on cardiorespiratory function of chronic obstructive pulmonary disease patients complicated with chronic cor pulmonale.Methods All the 106 stable phase chronic obstructive pulmonary disease patients with compensational chronic cor pulmonale were randomly divided into Shengmai group(n=50)and control group(n=56).Rehabilitation management and nutritional support were given routinely,and the Shengmai group was given an additional treatment(60 ml Shengmai injection added into 500 ml 5% glucose injection,iv by drip,Qd for 28 d).When beginning and termination of treatment,patients' pulmonary function test,blood gas analysis and ultrasonic echocardiography were performed,and 6-minute walking distance(6MWD) was recorded. Results Before the treatment,FEV_1,FEV_1/FVC,PaO_2,SaO_2 and PaCO_2 were not statistically differential(P>0.05).Comparing post-treatment with pre-treatment,FEV_1,FEV_1/FVC,PaO_2,SaO_2 and 6MWD showed various degree significant improvement in both group(P<0.05),while the improvement for Shengmai group was more significant(P<0.05).Restoration of increased right ventricular outflow tract and right ventricular internal diameter were observed in part of Shengmai group patients whereas not in control group. Conclusion Shengmai injection may improve the cardiorespiratory function of patients with stable phase chronic obstructive pulmonary disease complicated with compensational chronic cor pulmonale,and enhance their exercise tolerance.