Cyclin D1,Rb在胆管癌中的表达和意义

目的 探讨Cyclin D1,Rb的表达与胆管癌的临床病理参数和预后的关系。方法 采用S－P法进行Cyclin D1,Rb的免疫组化染色。结果 Cyclin D1的阳性表达率为52．38％（22／42），Cyclin D1的阳性表达与胆管癌的分化程度（P＝0．044），肝侵犯（P＝0．046），临床分期（P＝0．001），生存期（P＝0．0011）有关。Rb与胆管癌的分化程度（P＝0．0052）、临床分期（P＝0．0042）、淋巴结转移（P＝0．0068）有关。结论 Cyclin D1,Rb都与胆管癌的一些临床病理参数有关，Cyclin D1还是提示胆管癌预后的良好标志物。

Significance andexpression of Cyclin D1, Rb in bile duct carcinoma

Objective　To investigate the correlation between the expression of Cyclin D1,Rb and clinicopathologic parameter in bile duct carcinoma(BDC), and evaluate the potential prognostic value. MethodsThe expression of Cyclin D1, Rb in BDC was detected by immunochemical staining(S-P method). Results　Of 42 samples, 22 cases exhibited Cyclin D1 positive expression(52.38%), correlated with histological grade(P=0.044), hepatic invasion(P=0.0046), clinic stage(P=0.0001) and survival time(P=0.0011). The Rb positive rate was 57.14%(24/42), while the expression was related to histologic grade(P=0.0052), clinic stage(P=0.0042), and lymphatic metastasis(P=0.0068). Conclusions　Ccylin D1 and Rb are correlated with some clinicopathologic parameter of BDC, and Cyclin D1 is a valuable prognostic marker of BDC.